| pubmed-article:3967341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0007090 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C0000248 | lld:lifeskim |
| pubmed-article:3967341 | lifeskim:mentions | umls-concept:C1979928 | lld:lifeskim |
| pubmed-article:3967341 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3967341 | pubmed:dateCreated | 1985-3-20 | lld:pubmed |
| pubmed-article:3967341 | pubmed:abstractText | We determined ring- and N-hydroxylations of a systemic mammary gland carcinogen, N-2-fluorenylacetamide (2-FAA), by microsomal fractions of liver and mammary gland of female rats and the effects of in vivo and/or in vitro modifiers of these oxidations. Pretreatment of lactating rats with 3-methylcholanthrene (3-MC) or beta-naphthoflavone (beta-NF) and non-lactating (50-day old virgin) rats with beta-NF showed similar effects in that the formation of 3-, 5-, 7-, 9- and N-hydroxy-2-FAA by hepatic microsomes was increased manyfold and the formation of 1-hydroxy-2-FAA was induced. In mammary gland microsomes, the formation of 3-, 5- and 7-hydroxy-2-FAA was likewise increased, but of 9-hydroxy-2-FAA was unaffected. Only mammary microsomes of lactating rats had capacity for N-hydroxylation which was increased approximately 3 times by pretreatment of rats with 3-MC or beta-NF. All of the induced increases of metabolites of 2-FAA in hepatic and mammary microsomes were inhibited by 0.1 mM alpha-naphthoflavone (alpha-NF) in vitro. Pretreatment of non-lactating rats with phenobarbital increased only the formation of 7-hydroxy-2-FAA in hepatic microsomes which was further stimulated by alpha-NF in vitro. The latter also stimulated the formation of 7- and 9- hydroxy-2-FAA by hepatic microsomes of the uninduced rats, but had no effects in mammary microsomes, in which 9-hydroxy-2-FAA was a major metabolite. Hence, the data showed qualitative and quantitative differences between lactating and non-lactating rats in metabolism of 2-FAA by mammary microsomes which may result from differences in the levels (e.g., of cytochrome P-450) and activities of microsomal enzymes determined herein. In hepatic microsomes of these rats, differences in quantities of metabolites of 2-FAA (3-, 7-, 9- and N-hydroxy-2-FAA) were found in corn oil-treated rats only. The solvent (methanol or acetone) used for addition of 2-FAA to the incubation mixtures altered quantitatively the metabolite profiles in hepatic and mammary microsomes of 3-MC or beta-NF treated rats. The formations of 1- and 3- or 5- and 7-hydroxy-2-FAA were greater in the presence of acetone or methanol, respectively. The results of this study suggest that the formation of phenolic and N-hydroxy metabolites of 2-FAA in both hepatic and mammary microsomes of lactating rats is catalyzed by similar form(s) of cytochrome P-450 induced by pretreatment with 3-MC or beta-NF.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
| pubmed-article:3967341 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3967341 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3967341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3967341 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3967341 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:3967341 | pubmed:author | pubmed-author:Malejka-Gigan... | lld:pubmed |
| pubmed-article:3967341 | pubmed:author | pubmed-author:RitterC LCL | lld:pubmed |
| pubmed-article:3967341 | pubmed:author | pubmed-author:DeckerR WRW | lld:pubmed |
| pubmed-article:3967341 | pubmed:author | pubmed-author:PolovinaM RMR | lld:pubmed |
| pubmed-article:3967341 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3967341 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3967341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3967341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3967341 | pubmed:pagination | 95-103 | lld:pubmed |
| pubmed-article:3967341 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3967341 | pubmed:meshHeading | pubmed-meshheading:3967341-... | lld:pubmed |
| pubmed-article:3967341 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3967341 | pubmed:articleTitle | Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide. | lld:pubmed |
| pubmed-article:3967341 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3967341 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3967341 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3967341 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3967341 | lld:pubmed |
