| pubmed-article:3955347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C0012621 | lld:lifeskim |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C0009014 | lld:lifeskim |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:3955347 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3955347 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3955347 | pubmed:dateCreated | 1986-5-22 | lld:pubmed |
| pubmed-article:3955347 | pubmed:abstractText | Single-unit recordings of 50 pressure-sensitive neurons with axonal projections to the thoracic spinal cord were obtained in the retrofacial portion of nucleus paragigantocellularis lateralis of halothane-anesthetized rats. Two types of cells were distinguished on the basis of their axonal conduction velocities: a slow-conducting (mean 0.6 m/s, group I) and a fast-conducting one (group II, mean 3.3 m/s). Both cell types were completely silenced by elevating mean arterial pressure above 160 mm Hg by means of aortic constriction and exhibited a plateau of high spontaneous activity below 70 mm Hg. Only group I neurons were significantly inhibited by the administration of clonidine in a dose producing 90% of its maximum hypotensive effect (11.5 micrograms/kg, i.v.). Hypotensive doses of clonidine administered into the fourth ventricle also produced a selective inhibition of group I neurons, while the others were unaffected. Iontophoretic applications of clonidine and norepinephrine produced an inhibition of the discharges of group I neurons qualitatively and quantitatively identical to that observed following administration of clonidine by the i.v. or i.c.v. route. Once more, group II cells were unaffected. In contrast, iontophoretically applied gamma-aminobutyric acid exerted a powerful inhibition of both cell types, an effect which was totally prevented or reversed by the gamma-aminobutyric acid antagonist bicuculline. Anatomical experiments were performed to uncover the potential source of catecholaminergic innervation of the area in which recordings were obtained. This area contains a large number of adrenaline-synthesizing neurons and receives a selective noradrenergic input from the A5 pontine group with no contribution from the A1, A2, A6 and A7 brainstem clusters of noradrenergic cells. | lld:pubmed |
| pubmed-article:3955347 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3955347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3955347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3955347 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3955347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3955347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3955347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3955347 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3955347 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:3955347 | pubmed:author | pubmed-author:GuyenetP GPG | lld:pubmed |
| pubmed-article:3955347 | pubmed:author | pubmed-author:YUES JSJ | lld:pubmed |
| pubmed-article:3955347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3955347 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:3955347 | pubmed:volume | 368 | lld:pubmed |
| pubmed-article:3955347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3955347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3955347 | pubmed:pagination | 1-17 | lld:pubmed |
| pubmed-article:3955347 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3955347 | pubmed:meshHeading | pubmed-meshheading:3955347-... | lld:pubmed |
| pubmed-article:3955347 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3955347 | pubmed:articleTitle | Effect of clonidine and gamma-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in the rat. | lld:pubmed |
| pubmed-article:3955347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3955347 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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