| pubmed-article:3950546 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3950546 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:3950546 | lifeskim:mentions | umls-concept:C0005457 | lld:lifeskim |
| pubmed-article:3950546 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3950546 | pubmed:dateCreated | 1986-4-24 | lld:pubmed |
| pubmed-article:3950546 | pubmed:abstractText | A hybridoma antibody (11E7-1) was isolated from a myeloma fusion with nu/nu BALB/c immunized against the T15 idiotype. This IgM antibody exhibited a dual specificity, binding both to PC and to anti-PC antibodies from two idiotype families. Binding to PC and anti-PC antibodies are completely inhibited by PC analogs. Furthermore, the hybridoma antibody binds to itself. Self-binding is also inhibited by PC analogs. From these data, we suggest that 11E7-1 hybridoma antibody has a PC-specific paratope site, and at same time expresses the internal PC antigen idiotope. The term autobody is proposed to signify its self-binding and potential role in autoimmunity. Autobodies may have a unique role in the network of immune system. Furthermore, it may be a model for designing idiotype vaccines. | lld:pubmed |
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| pubmed-article:3950546 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3950546 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3950546 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3950546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3950546 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3950546 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3950546 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:3950546 | pubmed:author | pubmed-author:KohlerHH | lld:pubmed |
| pubmed-article:3950546 | pubmed:author | pubmed-author:KangC YCY | lld:pubmed |
| pubmed-article:3950546 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3950546 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3950546 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:3950546 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3950546 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3950546 | pubmed:pagination | 787-96 | lld:pubmed |
| pubmed-article:3950546 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
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| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:meshHeading | pubmed-meshheading:3950546-... | lld:pubmed |
| pubmed-article:3950546 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3950546 | pubmed:articleTitle | Immunoglobulin with complementary paratope and idiotope. | lld:pubmed |
| pubmed-article:3950546 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3950546 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3950546 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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