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pubmed-article:3945172pubmed:abstractTextCholine transport and levels were studied in erythrocytes from patients with Alzheimer's disease and age-matched controls using stable isotopic tracer techniques. The mean erythrocyte choline in the Alzheimer group was 50.1 nmol ml-1 compared to 15.5 nmol ml-1 in the controls. This was significant using a Student's t test at a P of less than 0.0005. Influx of choline into the erythrocyte correlated inversely with erythrocyte choline with high significance. This study suggests that erythrocyte choline is elevated in a subset of patients with Alzheimer's disease and that the low affinity transport system is also abnormal in these patients. This abnormality of choline transport may play a role in the pathogenesis of Alzheimer's disease in some patients.lld:pubmed
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pubmed-article:3945172pubmed:authorpubmed-author:JendenD JDJlld:pubmed
pubmed-article:3945172pubmed:authorpubmed-author:CummingsJ LJLlld:pubmed
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pubmed-article:3945172pubmed:pagination485-90lld:pubmed
pubmed-article:3945172pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:3945172pubmed:year1986lld:pubmed
pubmed-article:3945172pubmed:articleTitleAbnormal erythrocyte choline and influx in Alzheimer's disease.lld:pubmed
pubmed-article:3945172pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3945172pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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