| pubmed-article:3930971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3930971 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:3930971 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:3930971 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:3930971 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:3930971 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:3930971 | pubmed:issue | 6036 | lld:pubmed |
| pubmed-article:3930971 | pubmed:dateCreated | 1985-11-18 | lld:pubmed |
| pubmed-article:3930971 | pubmed:abstractText | In addition to expressing clonally distributed antigen-specific and major histocompatibility complex (MHC)-restricted receptors, T cells also express non-clonally distributed surface molecules that are involved in T-cell function. Among the most intriguing of the latter are L3T4 and Lyt 2, which are expressed on individual T lymphocytes in striking, though not absolute, concordance with their restriction by either class II or class I MHC determinants, and which are thought to contribute to the overall avidity of T-cell interactions by binding to monomorphic determinants on class II and class I MHC molecules, respectively. To examine the ability of T cells to recognize a single class II domain in the absence of the remainder of the Ia molecule, as well as to evaluate the structural basis for the putative interaction of L3T4 with Ia, a recombinant class II/class I murine MHC gene was constructed and introduced into mouse L cells. Here we demonstrate that a subset of class II allospecific cytotoxic T lymphocytes (CTL) can specifically recognize and lyse L-cell transfectants expressing an isolated polymorphic A beta 1 domain, and that anti-L3T4 antibody can block such killing, a result inconsistent with the highly conserved membrane-proximal domains of Ia acting as unique target sites for L3T4 binding. | lld:pubmed |
| pubmed-article:3930971 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3930971 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3930971 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3930971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3930971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3930971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3930971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3930971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3930971 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3930971 | pubmed:author | pubmed-author:SingerAA | lld:pubmed |
| pubmed-article:3930971 | pubmed:author | pubmed-author:GermainR NRN | lld:pubmed |
| pubmed-article:3930971 | pubmed:author | pubmed-author:GoldingHH | lld:pubmed |
| pubmed-article:3930971 | pubmed:author | pubmed-author:MarguliesD... | lld:pubmed |
| pubmed-article:3930971 | pubmed:author | pubmed-author:McCluskeyJJ | lld:pubmed |
| pubmed-article:3930971 | pubmed:author | pubmed-author:MunitzT ITI | lld:pubmed |
| pubmed-article:3930971 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3930971 | pubmed:volume | 317 | lld:pubmed |
| pubmed-article:3930971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3930971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3930971 | pubmed:pagination | 425-7 | lld:pubmed |
| pubmed-article:3930971 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3930971 | pubmed:meshHeading | pubmed-meshheading:3930971-... | lld:pubmed |
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| pubmed-article:3930971 | pubmed:meshHeading | pubmed-meshheading:3930971-... | lld:pubmed |
| pubmed-article:3930971 | pubmed:articleTitle | T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4. | lld:pubmed |
| pubmed-article:3930971 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3930971 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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