Linked Life Data

3927658

Source:http://linkedlifedata.com/resource/pubmed/id/3927658

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pubmed-article:3927658pubmed:abstractTextEffects of eight structurally closely related substituted urea herbicides were investigated on the induction of cytochrome P-450 dependent monooxygenase enzyme complex, as well as on two conjugating enzymes after short-term treatment of rats. Liver microsomal cytochrome P-450 content was induced approximately by 50%. Cytochrome P-450 dependent monooxygenase activities showed a great variety depending on the substrate and on the herbicide. Two-18-fold induction was detected with 7-ethoxycoumarin, while up to 8-fold induction was measured with benzo(a)pyrene. Aldrin epoxidase activities were increased up to 3-fold, and aminopyrine N-demethylase activities were only slightly different from the control level. UDP-glucuronyltransferase and glutathione S-transferase activities were enhanced up to 2-fold. The results indicate that chemical structure of the related substituted urea compounds, the number of halogen substituents on their phenyl group exert a strong influence on the induction of monooxygenases.lld:pubmed
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pubmed-article:3927658pubmed:articleTitleInduction of rat hepatic drug metabolizing enzymes by substituted urea herbicides.lld:pubmed
pubmed-article:3927658pubmed:publicationTypeJournal Articlelld:pubmed