| pubmed-article:3921823 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0006413 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0017473 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:3921823 | lifeskim:mentions | umls-concept:C1561491 | lld:lifeskim |
| pubmed-article:3921823 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3921823 | pubmed:dateCreated | 1985-6-6 | lld:pubmed |
| pubmed-article:3921823 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3921823 | pubmed:abstractText | We have cloned and sequenced the translocated c-myc gene from the Burkitt's lymphoma CA46 cell line that carries a reciprocal translocation between chromosomes 8 and 14. The breakpoint lies within the first intron of c-myc, so that the first noncoding exon of the gene remains on the 8q- chromosome. The second and third coding exons are translocated to the 14q+ chromosome into the switch region of C-alpha 1. The orientation of the c-myc gene with relationship to alpha 1 is 5' to 5', with directions of transcription in opposite orientation. DNA sequencing studies predict five changes in the amino acid sequence of the myc protein, two of which occur in a region within the second exon which is highly conserved in evolution. Southern blotting data indicate that the first exon of c-myc is rearranged 3' to 3' with the pseudo-epsilon gene. Because CA46 cells contain two rearranged mu genes, the translocation must have occurred after immunoglobulin rearrangement. The position of the breakpoint in CA46 occurs within a 20-base-pair region of the first intron of c-myc to which breakpoints have been mapped for two additional B-cell lymphomas with the t(8;14) translocation, ST486 and the Manca cell line. The region of the heavy chain locus to which c-myc has translocated is different in each case. Comparisons have been made of the levels of transcripts of the translocated c-myc gene in ST486 and CA46, where the gene is not associated with the heavy chain enhancer, with its expression in the Manca cell, in which it is. The c-myc gene is transcribed at similar levels in all three cases. | lld:pubmed |
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| pubmed-article:3921823 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3921823 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3921823 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3921823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3921823 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3921823 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3921823 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3921823 | pubmed:author | pubmed-author:NishikuraKK | lld:pubmed |
| pubmed-article:3921823 | pubmed:author | pubmed-author:CroceC MCM | lld:pubmed |
| pubmed-article:3921823 | pubmed:author | pubmed-author:KajiHH | lld:pubmed |
| pubmed-article:3921823 | pubmed:author | pubmed-author:EriksonJJ | lld:pubmed |
| pubmed-article:3921823 | pubmed:author | pubmed-author:ShoweL CLC | lld:pubmed |
| pubmed-article:3921823 | pubmed:author | pubmed-author:BallantineMM | lld:pubmed |
| pubmed-article:3921823 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3921823 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3921823 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3921823 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3921823 | pubmed:pagination | 501-9 | lld:pubmed |
| pubmed-article:3921823 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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