| pubmed-article:3920528 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3920528 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3920528 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:3920528 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:3920528 | lifeskim:mentions | umls-concept:C2825348 | lld:lifeskim |
| pubmed-article:3920528 | lifeskim:mentions | umls-concept:C0949374 | lld:lifeskim |
| pubmed-article:3920528 | pubmed:issue | 6008 | lld:pubmed |
| pubmed-article:3920528 | pubmed:dateCreated | 1985-4-29 | lld:pubmed |
| pubmed-article:3920528 | pubmed:abstractText | Proteins binding to specific regions of DNA with high affinity frequently govern or regulate reactions at the gene level. We have identified a high-affinity binding site in the immunoglobulin mu gene that binds a specific nuclear protein, and have now characterized it fully using nuclear factor 1 (NF-1), a protein purified from the nuclei of HeLa cells and required for the in vitro replication of adenovirus (Ad) DNA. NF-1 protects a 25-base pair (bp) double-stranded segment of DNA which shares a consensus sequence, 5' TGGA/CNNNNNGCCAA 3', with similar binding sites in the Ad-5 terminal repeat and the human c-myc gene. Although this site differs from the enhancer region, a biological function is suggested by the fact that it is DNase I hypersensitive in immunoglobulin-producing lymphoblastoid cells. The binding site for the NF-1 protein in the mu gene, by analogy with the site in the Ad-5 terminal repeat, may represent one component of a cellular origin of replication; alternatively, it may be responsible for the activation of the chromatin in this region. | lld:pubmed |
| pubmed-article:3920528 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3920528 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3920528 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3920528 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3920528 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:LederPP | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:SiebenlistUU | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:DannerDD | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:RosenfeldPP | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:HennighausenL... | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:RawlinsDD | lld:pubmed |
| pubmed-article:3920528 | pubmed:author | pubmed-author:KellyTTJr | lld:pubmed |
| pubmed-article:3920528 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3920528 | pubmed:volume | 314 | lld:pubmed |
| pubmed-article:3920528 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3920528 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3920528 | pubmed:pagination | 289-92 | lld:pubmed |
| pubmed-article:3920528 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3920528 | pubmed:articleTitle | High-affinity binding site for a specific nuclear protein in the human IgM gene. | lld:pubmed |
| pubmed-article:3920528 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3920528 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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