| pubmed-article:3893149 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3893149 | lifeskim:mentions | umls-concept:C0079773 | lld:lifeskim |
| pubmed-article:3893149 | lifeskim:mentions | umls-concept:C1609432 | lld:lifeskim |
| pubmed-article:3893149 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3893149 | pubmed:dateCreated | 1985-7-30 | lld:pubmed |
| pubmed-article:3893149 | pubmed:abstractText | In this study the authors attempted to establish immunopathologic criteria for the distinction of various T-cell lymphomas affecting the skin. We studied skin specimens from 27 patients with mycosis fungoides (MF) (n = 12), the Sézary syndrome (SS) (n = 6), adult T-cell leukemia (ATL) (n = 4), and nonepidermotropic T-cell lymphoma of large cell (n = 4) and lymphoblastic (n = 1) types. Identification of tumor cells in mixed cell populations and detection of weak expression of surface antigens by tumor cells was facilitated by immunoelectron microscopy. The mature helper T-cell phenotype (T11+ T3+ T4+) was found in 14 of 18 cases of MF/SS. One case of MF had a cytotoxic/suppressor (T4- T8+ 3A1+) phenotype; one with frequent blastic cells showed only weak expression of T4 antigen; 2 cases of SS were T11-. Tumor cells infiltrating the skin expressed 3Al antigen in 44% and cellular activation antigens Ia and/or Tac in 78% of patients with MF/SS. No consistent phenotypic differences were found between ATL cells from ATLV (HTLV) antibody-positive patients and tumor cells of patients with MF/SS who lacked this antibody. In contrast, a group of nonepidermotropic T-cell lymphomas showed phenotypic differences from MF/SS and ATL in all but 1 case. These cases were distinguished by the frequent absence of T3, T4, and Leu 1 antigens in 3 large-cell lymphomas; frequent expression of Ki-1 antigen, a Hodgkin's disease-associated antigen, in 2 cases with RS-like cells; and an immature thymocyte phenotype in lymphoblastic lymphoma. These findings demonstrate that tumor-cell phenotypes can be useful in distinguishing different histologic types of cutaneous T-cell lymphoma. | lld:pubmed |
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| pubmed-article:3893149 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3893149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3893149 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3893149 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3893149 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3893149 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:3893149 | pubmed:author | pubmed-author:KadinMM | lld:pubmed |
| pubmed-article:3893149 | pubmed:author | pubmed-author:NasuKK | lld:pubmed |
| pubmed-article:3893149 | pubmed:author | pubmed-author:VonderheidEE | lld:pubmed |
| pubmed-article:3893149 | pubmed:author | pubmed-author:SakaRR | lld:pubmed |
| pubmed-article:3893149 | pubmed:author | pubmed-author:SaidJJ | lld:pubmed |
| pubmed-article:3893149 | pubmed:author | pubmed-author:OlerudJJ | lld:pubmed |
| pubmed-article:3893149 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3893149 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:3893149 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3893149 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3893149 | pubmed:pagination | 436-47 | lld:pubmed |
| pubmed-article:3893149 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3893149 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3893149 | pubmed:articleTitle | Immunopathology of cutaneous T-cell lymphomas. | lld:pubmed |
| pubmed-article:3893149 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3893149 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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