| pubmed-article:38904 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:38904 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:38904 | lifeskim:mentions | umls-concept:C0144047 | lld:lifeskim |
| pubmed-article:38904 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:38904 | pubmed:dateCreated | 1979-11-29 | lld:pubmed |
| pubmed-article:38904 | pubmed:abstractText | Sulfato-trans-(-)-1,2-diaminocyclohexane platinum(II) is a new antitumor agent. Its effect on immune responses was investigated. This agent inhibited lymphocyte transformation in response to phytohemagglutinin, pokeweed mitogen, and concanavalin A. It inhibited antibody plaque-forming spleen cells in AKR/J mice at doses ranging from 2.5 to 7.5 mg/kg i.p. It also prolonged the survival of skin grafts against major histocompatibility barriers in C57BL/6J mice transplanted with tail skin from CBA/J mice. The effective dose ranged from 2.5 to 5 mg/kg. This compound inhibited graft-versus-host reaction in three-week-old AKR/J X DBA/2JF1 mice receiving spleen cells from AKR/J mice i.p. Significant inhibition of graft-versus-host reaction was seen with doses ranging from 1 to 7.5 mg/kg i.p. These results suggest that this drug is immunosuppressive. | lld:pubmed |
| pubmed-article:38904 | pubmed:language | eng | lld:pubmed |
| pubmed-article:38904 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:38904 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:38904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:38904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:38904 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:38904 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:38904 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:38904 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:38904 | pubmed:author | pubmed-author:HillJ MJM | lld:pubmed |
| pubmed-article:38904 | pubmed:author | pubmed-author:KhanAA | lld:pubmed |
| pubmed-article:38904 | pubmed:author | pubmed-author:HoganSS | lld:pubmed |
| pubmed-article:38904 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:38904 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:38904 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:38904 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:38904 | pubmed:pagination | 3476-8 | lld:pubmed |
| pubmed-article:38904 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-An... | lld:pubmed |
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| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Im... | lld:pubmed |
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| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Fe... | lld:pubmed |
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| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Do... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-An... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Im... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Mi... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Mi... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Gr... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Mi... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Mi... | lld:pubmed |
| pubmed-article:38904 | pubmed:meshHeading | pubmed-meshheading:38904-Or... | lld:pubmed |
| pubmed-article:38904 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:38904 | pubmed:articleTitle | Immunosuppressive effects of sulfato-trans-(-)-1,2-diaminocyclohexaneplatinum(II). | lld:pubmed |
| pubmed-article:38904 | pubmed:publicationType | Journal Article | lld:pubmed |
