| pubmed-article:3883347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3883347 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:3883347 | lifeskim:mentions | umls-concept:C0063164 | lld:lifeskim |
| pubmed-article:3883347 | lifeskim:mentions | umls-concept:C0752063 | lld:lifeskim |
| pubmed-article:3883347 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:3883347 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:3883347 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3883347 | pubmed:dateCreated | 1985-3-27 | lld:pubmed |
| pubmed-article:3883347 | pubmed:abstractText | The location inside rat liver parenchymal cells of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase; EC 1.1.1.34), the key regulatory enzyme in cholesterol biosynthesis, has been examined by immunoelectron microscopy and by subcellular fractionation. Although HMG-CoA reductase is generally thought to be exclusively a microsomal enzyme, we find that a substantial portion of cellular HMG-CoA reductase is localized in peroxisomes. Immunoelectron microscopic labeling of ultrathin frozen sections of normal rat liver, using two monoclonal antibodies to purified HMG-CoA reductase, showed that the enzyme is present in the peroxisomes at a higher concentration than at any other site inside the hepatocytes. Subcellular fractionation studies using Percoll and metrizamide gradients demonstrated a close correspondence of peaks of HMG-CoA reductase activity and of catalase activity, again revealing the presence of the reductase enzyme in peroxisomes. HMG-CoA reductase is therefore localized in peroxisomes in addition to being in the microsomal fraction. | lld:pubmed |
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| pubmed-article:3883347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3883347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3883347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3883347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3883347 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3883347 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3883347 | pubmed:author | pubmed-author:SingerS JSJ | lld:pubmed |
| pubmed-article:3883347 | pubmed:author | pubmed-author:ShapiroD JDJ | lld:pubmed |
| pubmed-article:3883347 | pubmed:author | pubmed-author:KellerG AGA | lld:pubmed |
| pubmed-article:3883347 | pubmed:author | pubmed-author:BartonM CMC | lld:pubmed |
| pubmed-article:3883347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3883347 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:3883347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3883347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3883347 | pubmed:pagination | 770-4 | lld:pubmed |
| pubmed-article:3883347 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:3883347 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3883347 | pubmed:articleTitle | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells. | lld:pubmed |
| pubmed-article:3883347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3883347 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3883347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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