| pubmed-article:3879814 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C1527200 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3879814 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3879814 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:3879814 | pubmed:dateCreated | 1986-10-3 | lld:pubmed |
| pubmed-article:3879814 | pubmed:abstractText | The cellular oncogene c-myc has been implicated in the regulation of growth of normal and neoplastic cells. Recently, it was suggested that c-myc gene expression may control the G0----G1-phase transition in normal lymphocytes that were stimulated to enter the cell cycle by the lectin concanavalin A (ConA). Here we describe the effects of purified recombinant interleukin 2 (rIL2) and of ConA on levels of c-myc mRNA in the noncytolytic murine T-cell clone L2. In contrast to resting (G0) primary cultures of lymphocytes, quiescent L2 cells have a higher RNA content than resting splenocytes and express receptors for interleukin 2 (IL2). Resting L2 cells are therefore best regarded as early G1-phase cells. Purified rIL2 was found to stimulate the rapid accumulation of c-myc mRNA in L2 cells. Levels of c-myc mRNA became maximal within 1 h and declined gradually thereafter. In contrast, ConA induced slower accumulation of c-myc mRNA in L2 cells, with increased levels of c-myc mRNA becoming detectable 4 to 8 h after stimulation. Experiments with the protein synthesis inhibitor cycloheximide demonstrated that the increase in levels of c-myc mRNA that were induced by ConA was a direct effect of this lectin and not secondary to IL2 production. Cyclosporin A, an immunosuppressive agent, markedly reduced the accumulation of c-myc mRNA that was induced by ConA but only slightly diminished the accumulation of c-myc mRNA that was induced by rIL2. Taken together, these data provide evidence that (i) c-myc gene expression can be regulated by at least two distinct pathways in T lymphocytes, only one of which is sensitive to cyclosporine A, and (ii) the accumulation of c-myc mRNA can be induced in T cells by IL2 during the G1 phase of the cell cycle. | lld:pubmed |
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| pubmed-article:3879814 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3879814 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3879814 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3879814 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3879814 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3879814 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3879814 | pubmed:author | pubmed-author:ReedJ CJC | lld:pubmed |
| pubmed-article:3879814 | pubmed:author | pubmed-author:PrystowskyM... | lld:pubmed |
| pubmed-article:3879814 | pubmed:author | pubmed-author:HooverR GRG | lld:pubmed |
| pubmed-article:3879814 | pubmed:author | pubmed-author:SabathD EDE | lld:pubmed |
| pubmed-article:3879814 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3879814 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3879814 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3879814 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3879814 | pubmed:pagination | 3361-8 | lld:pubmed |
| pubmed-article:3879814 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3879814 | pubmed:meshHeading | pubmed-meshheading:3879814-... | lld:pubmed |
| pubmed-article:3879814 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3879814 | pubmed:articleTitle | Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte. | lld:pubmed |
| pubmed-article:3879814 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3879814 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3879814 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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