| pubmed-article:3865193 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0027895 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C1561491 | lld:lifeskim |
| pubmed-article:3865193 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3865193 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:3865193 | pubmed:dateCreated | 1985-12-24 | lld:pubmed |
| pubmed-article:3865193 | pubmed:abstractText | Two peptides that crossreact with an antiserum raised against Phe-Met-Arg-Phe-NH2 were purified from bovine brain extract. Their structures were determined to be Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe- NH2 and Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2. The sequences were determined by gas-phase sequencing, except for the COOH-terminal phenylalaninamides. These were assigned on the basis of the reactivity of the peptides with the anti-Phe-Met-Arg-Phe-NH2 antiserum, which appears to recognize the determinant -Arg-Phe-NH2. Both peptides were synthesized, and the synthetic peptides were found to have the same HPLC retention times as the endogenous Phe-Met-Arg-Phe-NH2-immunoreactive peptides, thus confirming the assignment of phenylalaninamide to the COOH-terminal positions. Both of the synthetic peptides were found to decrease tail-flick latency in rats, and the octapeptide was more active than the octadecapeptide. The octapeptide was found also to attenuate the prolongation of the tail-flick latency induced by morphine. | lld:pubmed |
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| pubmed-article:3865193 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3865193 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3865193 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3865193 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3865193 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3865193 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3865193 | pubmed:author | pubmed-author:CostaEE | lld:pubmed |
| pubmed-article:3865193 | pubmed:author | pubmed-author:FrattaWW | lld:pubmed |
| pubmed-article:3865193 | pubmed:author | pubmed-author:YangH YHY | lld:pubmed |
| pubmed-article:3865193 | pubmed:author | pubmed-author:MajaneE AEA | lld:pubmed |
| pubmed-article:3865193 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3865193 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:3865193 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3865193 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3865193 | pubmed:pagination | 7757-61 | lld:pubmed |
| pubmed-article:3865193 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3865193 | pubmed:meshHeading | pubmed-meshheading:3865193-... | lld:pubmed |
| pubmed-article:3865193 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3865193 | pubmed:articleTitle | Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine. | lld:pubmed |
| pubmed-article:3865193 | pubmed:publicationType | Journal Article | lld:pubmed |
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