| pubmed-article:3862866 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0079382 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0023440 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0028621 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0220903 | lld:lifeskim |
| pubmed-article:3862866 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:3862866 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3862866 | pubmed:dateCreated | 1985-11-7 | lld:pubmed |
| pubmed-article:3862866 | pubmed:abstractText | Several antimetabolites have been demonstrated to have the capacity to initiate differentiation in vitro of a variety of leukemic cell lines. To explore the structural requirements for this activity, a series of purine and 8-substituted purine arabinofuranosyl and ribofuranosyl nucleoside derivatives were synthesized and tested as inducers of the differentiation of Friend murine erythroleukemia cells. 9-(beta-D-Arabinofuranosyl)hypoxanthine and 6-(hydroxyamino)-9-(beta-D-arabinofuranosyl)purine were effective inducers of maturation, producing 82% and 74% benzidine-positive cells, a measure of the number of cells synthesizing hemoglobin. 6-Mercapto-9-(beta-D-ribofuranosyl)purine and 6-(methylmercapto)-9-(beta-D-ribofuranosyl)purine and their corresponding beta-D-arabinofuranosyl derivatives were also effective initiators of maturation, causing approximately 50% of the cell population to assume a differentiated phenotype. | lld:pubmed |
| pubmed-article:3862866 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3862866 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3862866 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3862866 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3862866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3862866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3862866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3862866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3862866 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3862866 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3862866 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:3862866 | pubmed:author | pubmed-author:HAYD RDR | lld:pubmed |
| pubmed-article:3862866 | pubmed:author | pubmed-author:SartorelliA... | lld:pubmed |
| pubmed-article:3862866 | pubmed:author | pubmed-author:ChengJ CJC | lld:pubmed |
| pubmed-article:3862866 | pubmed:author | pubmed-author:IshiguroKK | lld:pubmed |
| pubmed-article:3862866 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3862866 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:3862866 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3862866 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3862866 | pubmed:pagination | 1481-5 | lld:pubmed |
| pubmed-article:3862866 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
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| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:meshHeading | pubmed-meshheading:3862866-... | lld:pubmed |
| pubmed-article:3862866 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3862866 | pubmed:articleTitle | Purine and 8-substituted purine arabinofuranosyl and ribofuranosyl nucleoside derivatives as potential inducers of the differentiation of the Friend erythroleukemia. | lld:pubmed |
| pubmed-article:3862866 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3862866 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:3862866 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3862866 | lld:pubmed |
