| pubmed-article:3858274 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C0040578 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C0205039 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C0012471 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C1293122 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C0178987 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C0444498 | lld:lifeskim |
| pubmed-article:3858274 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:3858274 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3858274 | pubmed:dateCreated | 1985-7-11 | lld:pubmed |
| pubmed-article:3858274 | pubmed:abstractText | We studied the effect of exogenous prostaglandin F2 alpha (PGF2 alpha) on airway smooth muscle contraction caused by parasympathetic stimulation in 22 mongrel dogs in situ. Voltage (0-30 V, constant 20 Hz) and frequency-response (0-25 Hz, 25 V) curves were generated by stimulating the cut ends of both cervical vagus nerves. Airway response was measured isometrically as active tension (AT) in a segment of cervical trachea and as change in airway resistance (RL) and dynamic compliance (Cdyn) in bronchial airways. One hour after 5 mg/kg iv indomethacin, a cumulative frequency-response curve was generated in nine animals by electrical stimulation of the vagus nerves at 15-s intervals. Reproducibility was demonstrated by generating a second curve 7 min later. A third frequency-response curve was generated during active contraction of the airway caused by continuous intravenous infusion of 10 micrograms X kg-1 X min-1PPGF2 alpha. Additional frequency-response studies were generated 15 and 30 min after PGF2 alpha, when airway contractile response (delta RL = +2.8 +/- 0.65 cmH2O X 1(-1) X s; delta Cdyn = -0.0259 +/- 0.007 1/cmH2O) returned to base line. Substantial augmentation of AT, RL, and Cdyn responses was demonstrated in every animal studied (P less than 0.01 for all points greater than 8 Hz) 15 min after PGF2 alpha. At 30 min, response did not differ from initial base-line control. In four animals receiving sham infusion, all frequency-response curves were identical. We demonstrate that PGF2 alpha augments the response to vagus nerve stimulation in tracheal and bronchial airways. Augmentation does not depend on PGF2 alpha-induced active tone. | lld:pubmed |
| pubmed-article:3858274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3858274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3858274 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3858274 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3858274 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3858274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3858274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3858274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3858274 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3858274 | pubmed:month | May | lld:pubmed |
| pubmed-article:3858274 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:3858274 | pubmed:author | pubmed-author:DavidA CAC | lld:pubmed |
| pubmed-article:3858274 | pubmed:author | pubmed-author:LeffA RAR | lld:pubmed |
| pubmed-article:3858274 | pubmed:author | pubmed-author:MunozN MNM | lld:pubmed |
| pubmed-article:3858274 | pubmed:author | pubmed-author:TalletJJ | lld:pubmed |
| pubmed-article:3858274 | pubmed:author | pubmed-author:CavigelliMM | lld:pubmed |
| pubmed-article:3858274 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3858274 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:3858274 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3858274 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3858274 | pubmed:pagination | 1558-64 | lld:pubmed |
| pubmed-article:3858274 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3858274 | pubmed:meshHeading | pubmed-meshheading:3858274-... | lld:pubmed |
| pubmed-article:3858274 | pubmed:meshHeading | pubmed-meshheading:3858274-... | lld:pubmed |
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| pubmed-article:3858274 | pubmed:meshHeading | pubmed-meshheading:3858274-... | lld:pubmed |
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| pubmed-article:3858274 | pubmed:meshHeading | pubmed-meshheading:3858274-... | lld:pubmed |
| pubmed-article:3858274 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3858274 | pubmed:articleTitle | Augmentation of parasympathetic contraction in tracheal and bronchial airways by PGF2 alpha in situ. | lld:pubmed |
| pubmed-article:3858274 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3858274 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3858274 | lld:pubmed |
