| pubmed-article:3855474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0016057 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0007994 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0022173 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0349590 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3855474 | lifeskim:mentions | umls-concept:C0597219 | lld:lifeskim |
| pubmed-article:3855474 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3855474 | pubmed:dateCreated | 1985-3-1 | lld:pubmed |
| pubmed-article:3855474 | pubmed:abstractText | Subcutaneous fibrosarcomas were induced chemically in mosaic mice heterozygous at the Pgk-1 locus on the X-chromosome. The normal tissues of these animals displayed two electrophoretically distinct isozymes of phosphoglycerate kinase-1-[(PGK-1) EC 2.7.2.3]. The tumors were carefully dissected and analyzed with respect to PGK-1 isozymes. A combination method of multiple sampling of the primary tumor and establishment of tissue culture cell lines from the tumor was utilized. A total of 82 samples was studied from 10 tumors developed in 9 mice. Twenty cell lines were established from 9 tumors; 6 of the tumors were shown to contain neoplastic cells of exclusively PGK-1B activity, 3 of the tumors were shown to contain neoplastic cells of exclusively PGK-1A activity, and 1 tumor contained neoplastic cells with both PGK-1A and PGK-1B activities. The tumor with both A and B activities was hourglass shaped, and the pattern of activity from multiple samples of this tumor suggests that it was formed by the coalescence of a PGK-1A and a PGK-1B tumor. The data presented are concordant with results from chimeric animals and spontaneous tumors in humans and indicate that these tumors display the behavior of clonal growths. | lld:pubmed |
| pubmed-article:3855474 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3855474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3855474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3855474 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3855474 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:3855474 | pubmed:author | pubmed-author:IannacconeP... | lld:pubmed |
| pubmed-article:3855474 | pubmed:author | pubmed-author:DeamantF DFD | lld:pubmed |
| pubmed-article:3855474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3855474 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:3855474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3855474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3855474 | pubmed:pagination | 145-50 | lld:pubmed |
| pubmed-article:3855474 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:meshHeading | pubmed-meshheading:3855474-... | lld:pubmed |
| pubmed-article:3855474 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3855474 | pubmed:articleTitle | Evidence concerning the clonal nature of chemically induced tumors: phosphoglycerate kinase-1 isozyme patterns in chemically induced fibrosarcomas. | lld:pubmed |
| pubmed-article:3855474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3855474 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3855474 | lld:pubmed |
