| pubmed-article:3855432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3855432 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:3855432 | lifeskim:mentions | umls-concept:C0205527 | lld:lifeskim |
| pubmed-article:3855432 | lifeskim:mentions | umls-concept:C0020855 | lld:lifeskim |
| pubmed-article:3855432 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:3855432 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:3855432 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:3855432 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3855432 | pubmed:dateCreated | 1985-3-20 | lld:pubmed |
| pubmed-article:3855432 | pubmed:abstractText | Genetic susceptibility to multiple sclerosis (MS) in Caucasians was previously shown to be correlated to the presence of given alleles at the HLA-DR and Gm loci. We now demonstrate that the humoral immune response in MS central nervous system (CNS) is modulated by both loci: the levels of IgG1 subclass and IgG1 allotypes in cerebrospinal fluid of MS patients depend on both their Gm genotype and their HLA-DR2 or HLA-DR7 phenotype. That HLA-DR molecules may either participate in a preferential recruitment of IgG1 allotype-producing B cells in MS CNS or act after such a selective homing is discussed. These results demonstrate that both HLA and Gm loci are synergistically involved in the modulation of the humoral immune response. | lld:pubmed |
| pubmed-article:3855432 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3855432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855432 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3855432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3855432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3855432 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3855432 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:SalierJ PJP | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:GoustJ MJM | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:SesboüéRR | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:GovaertsAA | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:SchullerEE | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:DegosJ DJD | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:DaveauMM | lld:pubmed |
| pubmed-article:3855432 | pubmed:author | pubmed-author:Martin-Mondie... | lld:pubmed |
| pubmed-article:3855432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3855432 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:3855432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3855432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3855432 | pubmed:pagination | 1551-4 | lld:pubmed |
| pubmed-article:3855432 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:meshHeading | pubmed-meshheading:3855432-... | lld:pubmed |
| pubmed-article:3855432 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3855432 | pubmed:articleTitle | HLA-DR-dependent variation of intrathecal IgG1 (Gm) allotype synthesis in multiple sclerosis. | lld:pubmed |
| pubmed-article:3855432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3855432 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3855432 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3855432 | lld:pubmed |
