| pubmed-article:3813075 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3813075 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:3813075 | lifeskim:mentions | umls-concept:C0231330 | lld:lifeskim |
| pubmed-article:3813075 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:3813075 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3813075 | pubmed:dateCreated | 1987-3-6 | lld:pubmed |
| pubmed-article:3813075 | pubmed:abstractText | The pharmacokinetics of morphine in ten infants less than or equal to 10 weeks of age who were receiving morphine infusions were determined. Infants 1-4 days of age (newborns) showed longer elimination half-lives than the older infants (6.8 vs. 3.9 h). Clearance in the newborns is less than one-half that found in older infants (6.3 vs. 23.8 ml X min-1 X kg-1). The combination of lower clearance and longer elimination half-life in newborns (0-7 days) may well explain a prolonged duration of action for morphine in very young infants, but other etiologies are needed to explain the respiratory sensitivity believed to persist in older infants. | lld:pubmed |
| pubmed-article:3813075 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3813075 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3813075 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3813075 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3813075 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3813075 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3813075 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3813075 | pubmed:issn | 0003-3022 | lld:pubmed |
| pubmed-article:3813075 | pubmed:author | pubmed-author:SlatteryJ TJT | lld:pubmed |
| pubmed-article:3813075 | pubmed:author | pubmed-author:LynnA MAM | lld:pubmed |
| pubmed-article:3813075 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3813075 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:3813075 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3813075 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3813075 | pubmed:pagination | 136-9 | lld:pubmed |
| pubmed-article:3813075 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3813075 | pubmed:meshHeading | pubmed-meshheading:3813075-... | lld:pubmed |
| pubmed-article:3813075 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3813075 | pubmed:articleTitle | Morphine pharmacokinetics in early infancy. | lld:pubmed |
| pubmed-article:3813075 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3813075 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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