| pubmed-article:3802082 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3802082 | lifeskim:mentions | umls-concept:C0041368 | lld:lifeskim |
| pubmed-article:3802082 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3802082 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3802082 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:3802082 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3802082 | pubmed:dateCreated | 1987-3-4 | lld:pubmed |
| pubmed-article:3802082 | pubmed:abstractText | Tumor necrosis factors (TNFs) are a class of cytokines secreted by activated effector cells involved in host defense against tumor progression. Epidermal growth factor (EGF) and recombinant human transforming growth factor-alpha (rHuTGF-alpha) were shown to interfere with the in vitro antiproliferative effects of recombinant human tumor necrosis factor-alpha (rHuTNF-alpha) and -beta on a human cervical carcinoma cell line, ME-180. The inhibitory effect could be observed at EGF or rHuTGF-alpha concentrations of 100 pg/ml, and was maximal between 1 and 10 ng/ml. This response was not due to down regulation of the TNF receptor or to alteration of the affinity of TNF-alpha for its receptor. Since the antiproliferative effect of recombinant human interferon-gamma was not significantly affected by the presence of EGF or rHuTGF-alpha, the inhibition was specific for recombinant TNFs and was not due solely to enhanced proliferation induced by the growth factors. Neither growth factor had a substantial protective effect on the synergistic cytotoxicity observed when tumor cells were exposed simultaneously to rHuTNF-alpha and recombinant human interferon-gamma. TGF-beta can also interfere with the antiproliferative effects of rHuTNF-alpha in vitro. At concentrations of less than 1 ng/ml, TGF-beta significantly antagonized the cytotoxic effects of rHuTNF-alpha on NIH 3T3 fibroblasts. Since EGF, platelet-derived growth factor, and TGF-beta all enhanced NIH 3T3 cell proliferation, but only TGF-beta interfered with rHuTNF-alpha cytotoxicity, the protective effects of TGF-beta were not related in a simple manner to enhanced cell proliferation. rHuTGF-alpha and TGF-beta did not have a significant protective effect against rHuTNF-alpha-mediated cytotoxicity on two other tumor cell lines, BT-20 and L-929 cells. Based upon these observations we suggest that growth factors might enhance tumor growth in vivo by a combination of distinct mechanisms: (a) by autocrine stimulation tumor cell growth; and/or (b) by interfering with normal effector mechanisms of host defense. | lld:pubmed |
| pubmed-article:3802082 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3802082 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3802082 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3802082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3802082 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3802082 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3802082 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:3802082 | pubmed:author | pubmed-author:ShepardH MHM | lld:pubmed |
| pubmed-article:3802082 | pubmed:author | pubmed-author:AggarwalB BBB | lld:pubmed |
| pubmed-article:3802082 | pubmed:author | pubmed-author:LewisG DGD | lld:pubmed |
| pubmed-article:3802082 | pubmed:author | pubmed-author:EessaluT ETE | lld:pubmed |
| pubmed-article:3802082 | pubmed:author | pubmed-author:SugarmanB JBJ | lld:pubmed |
| pubmed-article:3802082 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3802082 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3802082 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:3802082 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3802082 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3802082 | pubmed:pagination | 780-6 | lld:pubmed |
| pubmed-article:3802082 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:3802082 | pubmed:meshHeading | pubmed-meshheading:3802082-... | lld:pubmed |
| pubmed-article:3802082 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3802082 | pubmed:articleTitle | Effects of growth factors on the antiproliferative activity of tumor necrosis factors. | lld:pubmed |
| pubmed-article:3802082 | pubmed:publicationType | Journal Article | lld:pubmed |
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