Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:3802048rdf:typepubmed:Citationlld:pubmed
pubmed-article:3802048lifeskim:mentionsumls-concept:C0013227lld:lifeskim
pubmed-article:3802048lifeskim:mentionsumls-concept:C0042679lld:lifeskim
pubmed-article:3802048lifeskim:mentionsumls-concept:C1519249lld:lifeskim
pubmed-article:3802048lifeskim:mentionsumls-concept:C0220825lld:lifeskim
pubmed-article:3802048lifeskim:mentionsumls-concept:C0205195lld:lifeskim
pubmed-article:3802048lifeskim:mentionsumls-concept:C0733689lld:lifeskim
pubmed-article:3802048pubmed:issue4lld:pubmed
pubmed-article:3802048pubmed:dateCreated1987-2-26lld:pubmed
pubmed-article:3802048pubmed:abstractTextThe combination of vincristine and VP-16-213 has been found to have synergistic antitumor activity in a murine system in vivo when the sequence of drug administration was vincristine followed by VP-16-213. To investigate the potential influence of drug scheduling on this synergistic combination, the reverse sequence of drug administration was evaluated. DBA/2 mice were inoculated with 10(6) P-388 murine leukemia cells, after which saline only, VP-16-213 only, vincristine only, or VP-16-213 followed at various time intervals by vincristine, were administered. Probable cure (survival greater than 60 days) was observed in 0/20, 0/20, 0/120, and 46/115 (40%), respectively (p less than 0.001). The proportion of animals attaining probable cure was greatest in the group receiving vincristine 4-72 hours after VP-16-213 (40-50%). Similar results had been obtained previously with the reverse drug sequence. In this animal model, the synergistic antitumor activity of vincristine and VP-16-213 does not appear to be schedule-dependent with respect to the sequence of drug administration.lld:pubmed
pubmed-article:3802048pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3802048pubmed:languageenglld:pubmed
pubmed-article:3802048pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3802048pubmed:citationSubsetIMlld:pubmed
pubmed-article:3802048pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3802048pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3802048pubmed:statusMEDLINElld:pubmed
pubmed-article:3802048pubmed:monthOctlld:pubmed
pubmed-article:3802048pubmed:issn0305-7232lld:pubmed
pubmed-article:3802048pubmed:authorpubmed-author:JacksonD...lld:pubmed
pubmed-article:3802048pubmed:authorpubmed-author:MorganT MTMlld:pubmed
pubmed-article:3802048pubmed:authorpubmed-author:RiceD GDGlld:pubmed
pubmed-article:3802048pubmed:authorpubmed-author:LongT RTRlld:pubmed
pubmed-article:3802048pubmed:issnTypePrintlld:pubmed
pubmed-article:3802048pubmed:volume8lld:pubmed
pubmed-article:3802048pubmed:ownerNLMlld:pubmed
pubmed-article:3802048pubmed:authorsCompleteYlld:pubmed
pubmed-article:3802048pubmed:pagination265-75lld:pubmed
pubmed-article:3802048pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:meshHeadingpubmed-meshheading:3802048-...lld:pubmed
pubmed-article:3802048pubmed:year1986lld:pubmed
pubmed-article:3802048pubmed:articleTitleCombination vincristine and VP-16-213: evaluation of drug sequence.lld:pubmed
pubmed-article:3802048pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3802048pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:3802048pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:3802048pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed