| pubmed-article:3786376 | pubmed:abstractText | Studies of the stability of hydrochlorothiazide (1) in N-methylacetamide prove that a temperature dependent equilibrium is found in the isothermic short-term test as well as in the longterm stability test. Whereas the kinetic reaction evaluation after Arrhenius doesn't allow a forecast, the 25 degrees C-values, extrapolated after the Van't Hoff-equation, were confirmed using the long-term test. By adding the decomposition product aminodisulfamide (2) the hydrolysis is restricted. | lld:pubmed |
