| pubmed-article:3768005 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3768005 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:3768005 | lifeskim:mentions | umls-concept:C0021852 | lld:lifeskim |
| pubmed-article:3768005 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:3768005 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3768005 | pubmed:dateCreated | 1986-11-7 | lld:pubmed |
| pubmed-article:3768005 | pubmed:abstractText | Protein kinase C activity has been identified in cytosolic and membrane fractions from rat and rabbit small intestine epithelial cells. The cytosolic fraction comprised about the 75% of total activity. Protein kinase C activity was resolved from other protein kinase activities by ion exchange chromatography. Phosphatidylserine or phosphatidylinositol were required for protein kinase C to be active. In addition, the activity was enhanced by the presence of a diacylglycerol. Diolein and dimyristin were the most effective (13-14 fold activation). In the presence of phosphatidylserine and diolein, the Ka for activation by Ca2+ was 10(-7)M. The phorbol ester TPA substituted for diacylglycerol in activating protein kinase C. Brush border and basolateral membranes contained protein kinase C activity, although the specific activity of the basal lateral membranes was four-fold higher than the specific activity of the brush border membranes. The presence of PKC in small intestine epithelial cells might have important implications in the Ca2+ mediated control of ionic transport in this tissue. | lld:pubmed |
| pubmed-article:3768005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3768005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3768005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3768005 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3768005 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:3768005 | pubmed:author | pubmed-author:LazoP SPS | lld:pubmed |
| pubmed-article:3768005 | pubmed:author | pubmed-author:GascónSS | lld:pubmed |
| pubmed-article:3768005 | pubmed:author | pubmed-author:BarrowBB | lld:pubmed |
| pubmed-article:3768005 | pubmed:author | pubmed-author:DomínguezPP | lld:pubmed |
| pubmed-article:3768005 | pubmed:author | pubmed-author:VelascoGG | lld:pubmed |
| pubmed-article:3768005 | pubmed:author | pubmed-author:IglesiasC FCF | lld:pubmed |
| pubmed-article:3768005 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3768005 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:3768005 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:3768005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3768005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3768005 | pubmed:pagination | 875-82 | lld:pubmed |
| pubmed-article:3768005 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3768005 | pubmed:meshHeading | pubmed-meshheading:3768005-... | lld:pubmed |
| pubmed-article:3768005 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3768005 | pubmed:articleTitle | Protein kinase C from small intestine epithelial cells. | lld:pubmed |
| pubmed-article:3768005 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3768005 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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