| pubmed-article:3754460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3754460 | lifeskim:mentions | umls-concept:C0029266 | lld:lifeskim |
| pubmed-article:3754460 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:3754460 | lifeskim:mentions | umls-concept:C0038323 | lld:lifeskim |
| pubmed-article:3754460 | lifeskim:mentions | umls-concept:C0011744 | lld:lifeskim |
| pubmed-article:3754460 | lifeskim:mentions | umls-concept:C1959616 | lld:lifeskim |
| pubmed-article:3754460 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:3754460 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3754460 | pubmed:dateCreated | 1986-6-9 | lld:pubmed |
| pubmed-article:3754460 | pubmed:abstractText | Deuterium magnetic resonance spectra (55.26 MHz) of cholesterol-3 alpha-d1 and epicholesterol-3 beta-d1 in dipalmitoylglycerophosphocholine (DPPC) liposomes were measured as a function of sterol-to-phospholipid ratio below (24 degrees C) and above (60 degrees C) the phase transition temperature of DPPC. From the quadrupolar splittings delta vq, the molecular order parameters S describing the motions of the sterols in the bilayer were calculated, and the most probable angle of tilt alpha 0 of the molecular axis of the sterols relative to the bilayer normal was determined. We observed that the molecular axis of cholesterol in DPPC liposomes at both 24 and 60 degrees C is tilted at an angle of 16-19 degrees with the 3 beta-hydroxyl group projecting parallel to the bilayer normal into the aqueous interface. In contrast, at 24 degrees C, epicholesterol is aligned parallel (0 degrees) to the bilayer normal, placing the 3 alpha-hydroxyl group essentially perpendicular to the bilayer normal along the aqueous interface. At 60 degrees C, the average angle of epicholesterol (16-18 degrees) is similar to that of cholesterol, which can project the 3 alpha-hydroxyl group into the hydrophobic bilayer region. On the basis of the observed tilt angles of the two isomeric sterols in DPPC liposomes, a model is proposed that can rationalize the differential effects of cholesterol and epicholesterol on membrane properties.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:3754460 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3754460 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3754460 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3754460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3754460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3754460 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3754460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3754460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3754460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3754460 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3754460 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:3754460 | pubmed:author | pubmed-author:BaumannW JWJ | lld:pubmed |
| pubmed-article:3754460 | pubmed:author | pubmed-author:MurariRR | lld:pubmed |
| pubmed-article:3754460 | pubmed:author | pubmed-author:MurariM PMP | lld:pubmed |
| pubmed-article:3754460 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3754460 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:3754460 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:3754460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3754460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3754460 | pubmed:pagination | 1062-7 | lld:pubmed |
| pubmed-article:3754460 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:meshHeading | pubmed-meshheading:3754460-... | lld:pubmed |
| pubmed-article:3754460 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3754460 | pubmed:articleTitle | Sterol orientations in phosphatidylcholine liposomes as determined by deuterium NMR. | lld:pubmed |
| pubmed-article:3754460 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3754460 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3754460 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3754460 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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