| pubmed-article:3751110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0521378 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C1373178 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:3751110 | lifeskim:mentions | umls-concept:C0005052 | lld:lifeskim |
| pubmed-article:3751110 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3751110 | pubmed:dateCreated | 1986-9-26 | lld:pubmed |
| pubmed-article:3751110 | pubmed:abstractText | Approx. one-third of an i.v. dose of 14C-benzo[a]pyrene was excreted within four hours in the bile of guinea-pigs fed a normal diet. The extent of excretion was not altered by feeding high-fat or high-cholesterol diets. Hepatic cytochromes P-450 and b5, and benzo[a]pyrene hydroxylase activity were unaltered by the administration of high-fat and high-cholesterol diets. Pretreatment with low oral doses of benzo[a]pyrene (6 X 3 mg/kg) did not induce these parameters in animals given any of the diets. High-fat and high-cholesterol diets altered the pattern of benzo[a]pyrene metabolites in the bile, with significantly increased excretion of dihydrodiol glucuronides in both the high-fat and high-cholesterol groups. Hepatic epoxide hydrolase activity and glutathione content were unaltered by the high-fat or high-cholesterol diets, and therefore cannot explain the alteration in the profile of biliary metabolites of benzo[a]pyrene. The altered pattern of biliary excretion in animals fed high-fat or high-cholesterol diets would lead to an increase in the delivery to the colon of dihydrodiol metabolites of benzo[a]pyrene. | lld:pubmed |
| pubmed-article:3751110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3751110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3751110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3751110 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3751110 | pubmed:issn | 0049-8254 | lld:pubmed |
| pubmed-article:3751110 | pubmed:author | pubmed-author:RenwickA GAG | lld:pubmed |
| pubmed-article:3751110 | pubmed:author | pubmed-author:BowesS GSG | lld:pubmed |
| pubmed-article:3751110 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3751110 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:3751110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3751110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3751110 | pubmed:pagination | 531-42 | lld:pubmed |
| pubmed-article:3751110 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:meshHeading | pubmed-meshheading:3751110-... | lld:pubmed |
| pubmed-article:3751110 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3751110 | pubmed:articleTitle | The hepatic metabolism and biliary excretion of benzo[a]pyrene in guinea-pigs fed normal, high-fat or high-cholesterol diets. | lld:pubmed |
| pubmed-article:3751110 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3751110 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
