| pubmed-article:3746680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0041412 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0206428 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0009148 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:3746680 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:3746680 | pubmed:dateCreated | 1986-10-2 | lld:pubmed |
| pubmed-article:3746680 | pubmed:abstractText | Red-sensitive cone photoreceptors were isolated from the turtle retina, and GABA-induced currents were recorded under voltage clamp. The effect of Co2+, widely used as a blocker of chemical synapses, on the GABA-induced current was studied. Co2+ blocked the GABA-induced current evoked by local application either at the synaptic region (cone pedicle) or at the extra-synaptic region (cell body). 5 microM-Co2+ suppressed the GABA-induced current by 50%, and a few hundred microM-Co2+ blocked it almost completely. Co2+ suppressed the GABA-induced current non-competitively: the saturating response amplitude decreased without a change in the threshold or saturating dose of GABA. The blocking was not voltage dependent in the physiological range of the membrane potential. Ni2+ and Cd2+ also blocked the GABA-induced current non-competitively, and were as effective as Co2+. Tetraethylammonium (25 mM) showed a similar but weaker blocking effect. On the other hand, Mg2+ (20 mM), Mn2+, Sr2+, Ba2+ (10-100 microM each), D-600 (10 microM) or Cs+ (10 mM) did not affect the GABA-induced current. The Ca current in the turtle cones was blocked almost completely by 20 mM-Mg2+ or 4 mM-Co2+, or strongly suppressed by 10 microM-D-600. However, Cd2+ and Ni2+ (10 microM each) blocked the Ca current by ca. 50%, and Co2+ and Mn2+ (10 microM each) suppressed it only partially. The blocking of the GABA-induced current by these agents was, therefore, not directly related to the blocking of the Ca current and/or Ca-mediated currents. These observations present a warning on the use of some divalent cations, such as Co2+, Ni2+ or Cd2+, as a presynaptic blocker at the GABAergic synapse. High concentrations of Mg2+ are recommended as a more appropriate blocker. | lld:pubmed |
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| pubmed-article:3746680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3746680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3746680 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3746680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3746680 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3746680 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:3746680 | pubmed:author | pubmed-author:KanekoAA | lld:pubmed |
| pubmed-article:3746680 | pubmed:author | pubmed-author:TachibanaMM | lld:pubmed |
| pubmed-article:3746680 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3746680 | pubmed:volume | 373 | lld:pubmed |
| pubmed-article:3746680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3746680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3746680 | pubmed:pagination | 463-79 | lld:pubmed |
| pubmed-article:3746680 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3746680 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3746680 | pubmed:articleTitle | Blocking effects of cobalt and related ions on the gamma-aminobutyric acid-induced current in turtle retinal cones. | lld:pubmed |
| pubmed-article:3746680 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3746680 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3746680 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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