| pubmed-article:3741423 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3741423 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:3741423 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:3741423 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3741423 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:3741423 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:3741423 | lifeskim:mentions | umls-concept:C0231449 | lld:lifeskim |
| pubmed-article:3741423 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3741423 | pubmed:dateCreated | 1986-9-25 | lld:pubmed |
| pubmed-article:3741423 | pubmed:abstractText | Extraction of bovine pituitaries in the presence of enzyme inhibitors (2 mM PMSF, 2 mM sodium tetrathionate, 15 microM pepstatin A, and 1 mM EDTA) resulted in the isolation of two distinct forms of basic fibroblast growth factor. Partial characterization of both molecules showed one form to be identical to basic FGF(1-146) which has already been reported by our laboratory. The second form was estimated by SDS-PAGE to have a molecular weight of 17,000 Daltons which is slightly larger than that of basic FGF(1-146). Amino acid analysis shows the presence of 8 new residues more than basic FGF(1-146) which accounts for the difference in molecular weight. Gas-phase sequencing of this molecule indicated that it bears a blocked amino terminus. Furthermore, this higher molecular weight form of basic FGF did not show immunoreactivity with antibodies specific for the amino terminus of basic FGF(1-146) but cross reacted with antibodies generated against midportion fragments of basic FGF(1-146), indicating that the molecule is amino terminally extended. Like basic FGF(1-146), the molecule is a potent mitogenic factor for vascular endothelial cells. Taken together these results demonstrate the existence of a precursor form of basic FGF which is extended by 8 residues at the amino terminus with the first residue being blocked. | lld:pubmed |
| pubmed-article:3741423 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3741423 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3741423 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3741423 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3741423 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3741423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3741423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3741423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3741423 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3741423 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3741423 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:3741423 | pubmed:author | pubmed-author:GuilleminRR | lld:pubmed |
| pubmed-article:3741423 | pubmed:author | pubmed-author:LindKK | lld:pubmed |
| pubmed-article:3741423 | pubmed:author | pubmed-author:UenoNN | lld:pubmed |
| pubmed-article:3741423 | pubmed:author | pubmed-author:BairdAA | lld:pubmed |
| pubmed-article:3741423 | pubmed:author | pubmed-author:EschFF | lld:pubmed |
| pubmed-article:3741423 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3741423 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:3741423 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:3741423 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3741423 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3741423 | pubmed:pagination | 580-8 | lld:pubmed |
| pubmed-article:3741423 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:meshHeading | pubmed-meshheading:3741423-... | lld:pubmed |
| pubmed-article:3741423 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3741423 | pubmed:articleTitle | Isolation of an amino terminal extended form of basic fibroblast growth factor. | lld:pubmed |
| pubmed-article:3741423 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3741423 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3741423 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:281161 | entrezgene:pubmed | pubmed-article:3741423 | lld:entrezgene |
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