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pubmed-article:3734751pubmed:abstractTextThe DNA-intercalating agent ethidium bromide was used to eliminate plasmid DNA from streptomycetes. Other mutational events associated with chromosome changes occurred at high frequency; they resulted in phenotypic changes such as loss of enzyme activity, antibiotic resistance or ability to sporulate.lld:pubmed
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pubmed-article:3734751pubmed:articleTitlePlasmid curing and generation of mutations induced with ethidium bromide in streptomycetes.lld:pubmed
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