| pubmed-article:3696463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0020885 | lld:lifeskim |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0006931 | lld:lifeskim |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:3696463 | lifeskim:mentions | umls-concept:C0035028 | lld:lifeskim |
| pubmed-article:3696463 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:3696463 | pubmed:dateCreated | 1988-2-8 | lld:pubmed |
| pubmed-article:3696463 | pubmed:abstractText | The relaxant effect of capsaicin was investigated on isolated segments of guinea pig ileum precontracted by histamine. Two types of relaxation could be distinguished. Low concentrations of capsaicin (0.033-3.3 microM) caused partial relaxation (type I) which was prevented by in vitro desensitization to capsaicin or by extrinsic denervation and reduced by tachyphylaxis to calcitonin gene-related peptide. At higher concentrations (10-100 microM) capsaicin caused relaxation (type II) to the baseline; this effect was insensitive to capsaicin desensitization or extrinsic denervation. Neither type of relaxation was inhibited by tetrodotoxin or by alpha- and beta-adrenoceptor antagonists. We suggest that type I relaxation results from a specific effect of capsaicin on extrinsic sensory neurones of the gut while type II represents a non-specific smooth muscle depressant effect. Intrinsic enteric neurones are not involved in these effects. | lld:pubmed |
| pubmed-article:3696463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3696463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3696463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3696463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3696463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3696463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3696463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3696463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3696463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3696463 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3696463 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:3696463 | pubmed:author | pubmed-author:AntalAA | lld:pubmed |
| pubmed-article:3696463 | pubmed:author | pubmed-author:SzolcsányiJJ | lld:pubmed |
| pubmed-article:3696463 | pubmed:author | pubmed-author:BarthóLL | lld:pubmed |
| pubmed-article:3696463 | pubmed:author | pubmed-author:HolzerPP | lld:pubmed |
| pubmed-article:3696463 | pubmed:author | pubmed-author:PethöGG | lld:pubmed |
| pubmed-article:3696463 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3696463 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:3696463 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:3696463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3696463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3696463 | pubmed:pagination | 146-50 | lld:pubmed |
| pubmed-article:3696463 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
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| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
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| pubmed-article:3696463 | pubmed:meshHeading | pubmed-meshheading:3696463-... | lld:pubmed |
| pubmed-article:3696463 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3696463 | pubmed:articleTitle | Two types of relaxation due to capsaicin in the guinea pig isolated ileum. | lld:pubmed |
| pubmed-article:3696463 | pubmed:affiliation | Department of Pharmacology, University Medical School, Pécs, Hungary. | lld:pubmed |
| pubmed-article:3696463 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3696463 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3696463 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3696463 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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