| pubmed-article:3688217 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3688217 | lifeskim:mentions | umls-concept:C0814997 | lld:lifeskim |
| pubmed-article:3688217 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:3688217 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:3688217 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:3688217 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:3688217 | pubmed:dateCreated | 1988-1-6 | lld:pubmed |
| pubmed-article:3688217 | pubmed:abstractText | The unidirectional influx of 36Cl- into isolated chick epithelial cells is 30% inhibited by 300 microM SITS. Characteristics of the SITS-sensitive flux pathway were examined in terms of sensitivity to changes in membrane potential and intracellular pH. Potential dependence was evaluated using unidirectional influx of [14C]tetraphenylphosphonium ([14C]-TPP+) as a qualitative sensor of diffusion potentials created by experimentally imposed gradients of Cl-. Steady-state distribution of [14C]methylamine ([14C]MA) was used to examine for Cl(-)-dependent changes in intracellular pH. Imposed Na+ gradients, but not Cl- gradients, induce changes in [14C]MA distribution. SITS does not alter the [14C]MA distribution observed in cells with imposed gradients of Na+ and Cl-. Both results suggest that inhibition of Cl(-)-OH- exchange system is not the basis for the SITS effect on Cl- influx. However, if relative permeabilities for ion pairs via conductance pathways are compared, it can be shown that SITS causes a marked reduction of Pcl relative to either PNa or PK. SITS also inhibits electrically induced influx of [14C]TPP+ or [14C] alpha-methylglucoside driven by imposed Cl- gradients. Conversely, electrically driven Cl- influx can be blocked by SITS. These observations are all consistent with a SITS-sensitive Cl- conductance pathway associated with the plasma membrane of chick intestinal cells. No Cl(-)-OH- exchange capability can be detected for chick intestinal cells. | lld:pubmed |
| pubmed-article:3688217 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3688217 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3688217 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3688217 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3688217 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3688217 | pubmed:author | pubmed-author:KimmichG AGA | lld:pubmed |
| pubmed-article:3688217 | pubmed:author | pubmed-author:RandlesJJ | lld:pubmed |
| pubmed-article:3688217 | pubmed:author | pubmed-author:MontroseMM | lld:pubmed |
| pubmed-article:3688217 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3688217 | pubmed:volume | 253 | lld:pubmed |
| pubmed-article:3688217 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3688217 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3688217 | pubmed:pagination | C693-9 | lld:pubmed |
| pubmed-article:3688217 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3688217 | pubmed:meshHeading | pubmed-meshheading:3688217-... | lld:pubmed |
| pubmed-article:3688217 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3688217 | pubmed:articleTitle | SITS-sensitive Cl- conductance pathway in chick intestinal cells. | lld:pubmed |
| pubmed-article:3688217 | pubmed:affiliation | Department of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, New York 14642. | lld:pubmed |
| pubmed-article:3688217 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3688217 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3688217 | lld:pubmed |
