| pubmed-article:3680602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0205653 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0684224 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0028420 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C1705911 | lld:lifeskim |
| pubmed-article:3680602 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:3680602 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3680602 | pubmed:dateCreated | 1988-1-11 | lld:pubmed |
| pubmed-article:3680602 | pubmed:abstractText | This is the final report of a study of single dose pharmacokinetic parameters of nortriptyline in children and adolescents 5 to 16 years old (N = 64). The data were analyzed separately for the 5- to 12-year-olds (N = 41) and for the 13- to 16-year-olds (N = 32). The results confirm the preliminary findings of the similarity of the pharmacology of nortriptyline between the pediatric and adult age groups with respect to a logarithmically linear rate of elimination and a wide interindividual rate of metabolism. The 5- to 12-year-olds had a significantly shorter mean half-life and a significantly greater mean apparent oral clearance than the 13- to 16-year-olds. The mean half-life in the 5- to 12-year-olds was 20.8 +/- 7.2 (range, 11.2 to 42.5) hours and in the 13- to 16-year-olds was 31.1 +/- 19.8 (range, 14.2 to 89.4) hours. A twice a day dosage regimen is recommended for the entire 5- to 16-year-old group based on their range of half-lives. | lld:pubmed |
| pubmed-article:3680602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3680602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3680602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3680602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3680602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3680602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3680602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3680602 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3680602 | pubmed:issn | 0271-0749 | lld:pubmed |
| pubmed-article:3680602 | pubmed:author | pubmed-author:CooperT BTB | lld:pubmed |
| pubmed-article:3680602 | pubmed:author | pubmed-author:GellerBB | lld:pubmed |
| pubmed-article:3680602 | pubmed:author | pubmed-author:CarrL GLG | lld:pubmed |
| pubmed-article:3680602 | pubmed:author | pubmed-author:SchluchterM... | lld:pubmed |
| pubmed-article:3680602 | pubmed:author | pubmed-author:WarhamJ EJE | lld:pubmed |
| pubmed-article:3680602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3680602 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:3680602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3680602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3680602 | pubmed:pagination | 321-3 | lld:pubmed |
| pubmed-article:3680602 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:meshHeading | pubmed-meshheading:3680602-... | lld:pubmed |
| pubmed-article:3680602 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3680602 | pubmed:articleTitle | Child and adolescent nortriptyline single dose pharmacokinetic parameters: final report. | lld:pubmed |
| pubmed-article:3680602 | pubmed:affiliation | Childhood Affective Disorders Program, William S. Hall Psychiatric Institute, Columbia, South Carolina 29202. | lld:pubmed |
| pubmed-article:3680602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3680602 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3680602 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3680602 | lld:pubmed |
