| pubmed-article:3676595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C0023542 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3676595 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:3676595 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3676595 | pubmed:dateCreated | 1987-12-24 | lld:pubmed |
| pubmed-article:3676595 | pubmed:abstractText | 1 The vascular effects of leukotriene C4 (LTC4) were investigated in the isolated perfused kidney of the rat. 2 LTC4 (6.4 X 10(-10) to 3.2 X 10(-8) mol kg-1 min-1 given over 5 min) resulted in a prompt, dose-dependent increase in renal vascular resistance in a recirculating system, which lasted for more than 60 min. 3 LTC4 was 10 to 20 fold and 1000 to 2000 fold, respectively, less active on a molar basis than noradrenaline and angiotensin II in eliciting renal vasoconstriction. 4 The vascular response to LTC4 was blocked dose-dependently by FPL 55712, an antagonist of slow reacting substance of anaphylaxis. OKY 1581, a specific thromboxane synthetase inhibitor, and indomethacin, a cyclo-oxygenase inhibitor, did not influence the LTC4 response. 5 LTC4 given in a single-pass perfusion system resulted in a short lasting response with baseline values for renal vascular resistance reached after 4 min. 6 These results show that LTC4 is a short acting renal vasoconstrictor with less potency than noradrenaline and angiotensin II. Its pressor effects seem to be mediated by specific leukotriene receptors and independent of cyclo-oxygenase products. The long-lasting effect in the recirculating arrangement, in contrast to the single pass system, is compatible with formation of active metabolite(s). | lld:pubmed |
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| pubmed-article:3676595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3676595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3676595 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3676595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3676595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3676595 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3676595 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:3676595 | pubmed:author | pubmed-author:FrölichJ CJC | lld:pubmed |
| pubmed-article:3676595 | pubmed:author | pubmed-author:YoshizawaMM | lld:pubmed |
| pubmed-article:3676595 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3676595 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:3676595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3676595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3676595 | pubmed:pagination | 311-8 | lld:pubmed |
| pubmed-article:3676595 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3676595 | pubmed:meshHeading | pubmed-meshheading:3676595-... | lld:pubmed |
| pubmed-article:3676595 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3676595 | pubmed:articleTitle | Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat. | lld:pubmed |
| pubmed-article:3676595 | pubmed:affiliation | Department of Clinical Pharmacology, Hannover Medical School, Germany. | lld:pubmed |
| pubmed-article:3676595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3676595 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3676595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3676595 | lld:pubmed |
