| pubmed-article:3671445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C0008372 | lld:lifeskim |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C0005576 | lld:lifeskim |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3671445 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:3671445 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3671445 | pubmed:dateCreated | 1987-11-25 | lld:pubmed |
| pubmed-article:3671445 | pubmed:abstractText | The elimination of caffeine from plasma and the excretion of the main metabolites of metamizol (noramidopyrinemethanesulphonate sodium) into the urine were determined in healthy pregnant women (weeks 30-38 of pregnancy) and in patients with intrahepatic cholestasis in pregnancy (weeks 28-39 of pregnancy). From the elimination velocity of these model substances conclusions concerning the activity of 3-methylcholanthrene (caffeine elimination) and phenobarbital inducible isoenzymes (metamizol elimination) of cytochrome P-450 are drawn. Patients with intrahepatic cholestasis in pregnancy (t1/2 = 15.8 +/- 1.8 h) eliminate caffeine more slowly than healthy pregnant women (t1/2 = 11.0 +/- 0.8 h) at this stage of pregnancy. The excretion of the metabolites of metamizol is only in tendency diminished in patients with intrahepatic cholestasis. The influence of the intrahepatic cholestasis on the cytochrome P-450 isoenzymes investigated differs in degree. | lld:pubmed |
| pubmed-article:3671445 | pubmed:language | ger | lld:pubmed |
| pubmed-article:3671445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3671445 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3671445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3671445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3671445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3671445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3671445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3671445 | pubmed:month | May | lld:pubmed |
| pubmed-article:3671445 | pubmed:issn | 0031-7144 | lld:pubmed |
| pubmed-article:3671445 | pubmed:author | pubmed-author:SplinterF KFK | lld:pubmed |
| pubmed-article:3671445 | pubmed:author | pubmed-author:SiegertCC | lld:pubmed |
| pubmed-article:3671445 | pubmed:author | pubmed-author:PeikerGG | lld:pubmed |
| pubmed-article:3671445 | pubmed:author | pubmed-author:TraegerAA | lld:pubmed |
| pubmed-article:3671445 | pubmed:author | pubmed-author:OrtweilerWW | lld:pubmed |
| pubmed-article:3671445 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3671445 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:3671445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3671445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3671445 | pubmed:pagination | 329-31 | lld:pubmed |
| pubmed-article:3671445 | pubmed:dateRevised | 2007-1-29 | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:meshHeading | pubmed-meshheading:3671445-... | lld:pubmed |
| pubmed-article:3671445 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3671445 | pubmed:articleTitle | [The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions]. | lld:pubmed |
| pubmed-article:3671445 | pubmed:affiliation | Institut für Pharmakologie und Toxikologie, Friedrich Schiller-Universität Jena. | lld:pubmed |
| pubmed-article:3671445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3671445 | pubmed:publicationType | English Abstract | lld:pubmed |
