| pubmed-article:3664086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3664086 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:3664086 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:3664086 | lifeskim:mentions | umls-concept:C0042305 | lld:lifeskim |
| pubmed-article:3664086 | lifeskim:mentions | umls-concept:C0079043 | lld:lifeskim |
| pubmed-article:3664086 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3664086 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3664086 | pubmed:dateCreated | 1987-12-16 | lld:pubmed |
| pubmed-article:3664086 | pubmed:abstractText | 1 The characteristics of vanadate-induced bronchoconstriction and airways hyperreactivity were observed in spontaneously breathing anaesthetized guinea-pigs by measurement of airways resistance (Raw) and dynamic lung compliance (Cdyn). Vanadate (0.3-3 mg kg-1 i.v. over 25 min) increased Raw and decreased Cdyn in a reversible, dose-related manner. This action (1 mg kg-1 vanadate) was not inhibited by atropine (1 mg kg-1 i.v.), propranolol (1 mg kg-1 i.v.) or bilateral vagotomy, suggesting a direct effect on the airways smooth muscle. 2 An aerosol of vanadate (10% w/v in H2O) for 3 min decreased Cdyn by 19.5% (P less than 0.05, n = 6) but caused no change in Raw. 3 Histamine (3 micrograms kg-1 i.v.) caused a bronchoconstriction which was enhanced by vanadate in a dose-related manner. This hyperreactivity (after 1 mg kg-1 i.v. vanadate) was unchanged after propranolol or bilateral vagotomy, but was partly blocked by atropine (enhancement by vanadate of the Cdyn change to histamine was diminished, P less than 0.02, n = 3). 4 Bronchoconstrictor responses to acetylcholine (6 micrograms kg-1 i.v.) and 5-hydroxytryptamine (6 micrograms kg-1 i.v.) were also enhanced by vanadate (1 mg kg-1 i.v.) Hyperreactivity after vanadate to the three bronchoconstrictors tested continued during vanadate infusion and was reversed 45 min after cessation of infusion. 5 Histamine (3 ;Lgkg-' i.v.) caused a transient tachypnoea which was also enhanced by vanadate (0.3-3mgkg-'i.v.), in a dose-related manner, in association with the increased reactivity of the airways (r = 0.66, n = 11). 6 It is concluded that vanadate-induced airways hyperreactivity is non-vagal (efferent) and largely non-cholinergic in origin and appears to involve an action of vanadate within the lung itself. | lld:pubmed |
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| pubmed-article:3664086 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3664086 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3664086 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3664086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3664086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3664086 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3664086 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:3664086 | pubmed:author | pubmed-author:MitchellH WHW | lld:pubmed |
| pubmed-article:3664086 | pubmed:author | pubmed-author:NaylerR ARA | lld:pubmed |
| pubmed-article:3664086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3664086 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:3664086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3664086 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3664086 | pubmed:pagination | 173-80 | lld:pubmed |
| pubmed-article:3664086 | pubmed:dateRevised | 2010-5-10 | lld:pubmed |
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| pubmed-article:3664086 | pubmed:meshHeading | pubmed-meshheading:3664086-... | lld:pubmed |
| pubmed-article:3664086 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3664086 | pubmed:articleTitle | Airways hyperreactivity and bronchoconstriction induced by vanadate in the guinea-pig. | lld:pubmed |
| pubmed-article:3664086 | pubmed:affiliation | Department of Physiology, University of Western Australia, Nedlands. | lld:pubmed |
| pubmed-article:3664086 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3664086 | lld:pubmed |
