| pubmed-article:3663701 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3663701 | lifeskim:mentions | umls-concept:C0042874 | lld:lifeskim |
| pubmed-article:3663701 | lifeskim:mentions | umls-concept:C0199176 | lld:lifeskim |
| pubmed-article:3663701 | lifeskim:mentions | umls-concept:C0023775 | lld:lifeskim |
| pubmed-article:3663701 | lifeskim:mentions | umls-concept:C2346593 | lld:lifeskim |
| pubmed-article:3663701 | lifeskim:mentions | umls-concept:C0599918 | lld:lifeskim |
| pubmed-article:3663701 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3663701 | pubmed:dateCreated | 1987-12-11 | lld:pubmed |
| pubmed-article:3663701 | pubmed:abstractText | Iron and aluminum complexes of nitrilotriacetic acid cause severe nephrotoxicity in Wistar rats. In addition, a high incidence of renal cell carcinoma is seen in ferric nitrilotriacetate-treated animals. The present study was performed to see if lipid peroxidation is involved in ferric nitrilotriacetate toxicity. Ferric nitrilotriacetate had more bleomycin-detectable 'free' iron than any ferric salt, while iron complexed with desferrioxamine or ferric chondroitin sulfate had none. The toxicity of ferric nitrilotriacetate in vivo was more pronounced in vitamin E-deficient rats. A thiobarbituric acid-reactive substance was present in the kidneys of vitamin E-deficient rats in amounts markedly elevated compared to vitamin E-sufficient, or vitamin E-supplemented rats. Non-complexed nitrilotriacetate or aluminum nitrilotriacetate did not produce any thiobarbituric acid-reactive substance in vitamin E-sufficient rats died by the 58th day of administration. We suggest that the iron-stimulated production of free radicals leading to lipid peroxidation is the major cause of ferric nitrilotriacetate-mediated renal toxicity. Vitamin E, a known scavenger of free radicals, is effective in protecting against this iron-induced toxicity. | lld:pubmed |
| pubmed-article:3663701 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3663701 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3663701 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3663701 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3663701 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:3663701 | pubmed:author | pubmed-author:OkadaSS | lld:pubmed |
| pubmed-article:3663701 | pubmed:author | pubmed-author:MidorikawaOO | lld:pubmed |
| pubmed-article:3663701 | pubmed:author | pubmed-author:EilCC | lld:pubmed |
| pubmed-article:3663701 | pubmed:author | pubmed-author:EbinaYY | lld:pubmed |
| pubmed-article:3663701 | pubmed:author | pubmed-author:HamazakiSS | lld:pubmed |
| pubmed-article:3663701 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3663701 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:3663701 | pubmed:volume | 922 | lld:pubmed |
| pubmed-article:3663701 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3663701 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3663701 | pubmed:pagination | 28-33 | lld:pubmed |
| pubmed-article:3663701 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
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| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
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| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:meshHeading | pubmed-meshheading:3663701-... | lld:pubmed |
| pubmed-article:3663701 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3663701 | pubmed:articleTitle | Nephrotoxicity and its prevention by vitamin E in ferric nitrilotriacetate-promoted lipid peroxidation. | lld:pubmed |
| pubmed-article:3663701 | pubmed:affiliation | Department of Pathology, Faculty of Medicine, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:3663701 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3663701 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3663701 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3663701 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3663701 | lld:pubmed |
