| pubmed-article:3630723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3630723 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:3630723 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:3630723 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:3630723 | lifeskim:mentions | umls-concept:C0521378 | lld:lifeskim |
| pubmed-article:3630723 | lifeskim:mentions | umls-concept:C0002502 | lld:lifeskim |
| pubmed-article:3630723 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3630723 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3630723 | pubmed:dateCreated | 1987-9-29 | lld:pubmed |
| pubmed-article:3630723 | pubmed:abstractText | The present study was performed on 29 anaesthetized pigs and shows that the bile acid ursodeoxycholic acid (UDCA) produces a flow of bile rich in HCO3- compared with taurocholic acid (TCA). The slope relating biliary HCO3- secretion to bile acid secretion was 0.59 (0.44-0.82) and 0.33 (0.29-0.38) during venous infusion of UDCA and TCA, respectively. We next wanted to evaluate the importance of Na+/H+ ion exchange for biliary HCO3- secretion. High doses of amiloride were employed in order to impair the hepatic Na+/H+ ion exchanger. It was reasoned that any reduction in H+ efflux through the hepatic Na+/H+ ion exchanger involved in causing biliary HCO3- secretion would be translated into an equimolar fall in biliary HCO3- secretion. We found that amiloride (2.0 X 10(-4) mol l-1 plasma) reduced UDCA-dependent canalicular HCO3- secretion by 26 (14-35)% without concurrently reducing bile acid secretion. Amiloride (2.9 X 10(-4) mol l-1 plasma) did not significantly reduce secretin-dependent ductular HCO3- secretion. In this group of animals amiloride reduced bile acid secretion by 13 (5-22)%. It is concluded that Na+/H+ ion exchanger is essential for UDCA-dependent canalicular HCO3- secretion, but not for secretin-dependent ductular HCO3- secretion. | lld:pubmed |
| pubmed-article:3630723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3630723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3630723 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3630723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3630723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3630723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3630723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3630723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3630723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3630723 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3630723 | pubmed:issn | 0001-6772 | lld:pubmed |
| pubmed-article:3630723 | pubmed:author | pubmed-author:RaederM GMG | lld:pubmed |
| pubmed-article:3630723 | pubmed:author | pubmed-author:GrotmolTT | lld:pubmed |
| pubmed-article:3630723 | pubmed:author | pubmed-author:BuanesTT | lld:pubmed |
| pubmed-article:3630723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3630723 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:3630723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3630723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3630723 | pubmed:pagination | 447-55 | lld:pubmed |
| pubmed-article:3630723 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:meshHeading | pubmed-meshheading:3630723-... | lld:pubmed |
| pubmed-article:3630723 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3630723 | pubmed:articleTitle | The effect of amiloride on biliary HCO3- secretion in the anaesthetized pig. | lld:pubmed |
| pubmed-article:3630723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3630723 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3630723 | lld:pubmed |
