| pubmed-article:3627144 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:3627144 | lifeskim:mentions | umls-concept:C0597094 | lld:lifeskim |
| pubmed-article:3627144 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3627144 | pubmed:dateCreated | 1987-10-6 | lld:pubmed |
| pubmed-article:3627144 | pubmed:abstractText | The limited DNA excision repair that occurs in the chromatin of UV-irradiated growth arrested cells isolated from a xeroderma pigmentosum (XP) complementation group C patient is clustered in localized regions. The repaired DNA was found to be more sensitive to nicking by endogenous nucleases than the bulk of the DNA. The extra-sensitivity does not change with increasing amounts of DNA damage or repair activity in the locally-repaired regions and is retained through a 24-h chase period. We suggest that these results are due to the occurrence of DNA repair limited to pre-existing, non-transient chromatin fractions that contain actively transcribed DNA. A similar extra-sensitivity of repaired DNA was not detected in cells of normal or XP complementation group A strains that exhibit either normal or limited repair located randomly throughout their genomes. The association between endogenous nuclease sensitivity and clustered repair probably defines a normal excision repair pathway that is specific for selected chromatin domains. The repair defect in XP-C strains may be one in pathways targeted for other endogenous nuclease-resistant domains. | lld:pubmed |
| pubmed-article:3627144 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3627144 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3627144 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3627144 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3627144 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3627144 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3627144 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3627144 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3627144 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:3627144 | pubmed:author | pubmed-author:KantorG JGJ | lld:pubmed |
| pubmed-article:3627144 | pubmed:author | pubmed-author:PlayerA NAN | lld:pubmed |
| pubmed-article:3627144 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3627144 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:3627144 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3627144 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3627144 | pubmed:pagination | 169-78 | lld:pubmed |
| pubmed-article:3627144 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:meshHeading | pubmed-meshheading:3627144-... | lld:pubmed |
| pubmed-article:3627144 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3627144 | pubmed:articleTitle | The endogenous nuclease sensitivity of repaired DNA in human fibroblasts. | lld:pubmed |
| pubmed-article:3627144 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3627144 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3627144 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3627144 | lld:pubmed |
