| pubmed-article:360214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:360214 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:360214 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:360214 | lifeskim:mentions | umls-concept:C0004793 | lld:lifeskim |
| pubmed-article:360214 | lifeskim:mentions | umls-concept:C0031453 | lld:lifeskim |
| pubmed-article:360214 | lifeskim:mentions | umls-concept:C0029073 | lld:lifeskim |
| pubmed-article:360214 | lifeskim:mentions | umls-concept:C2242140 | lld:lifeskim |
| pubmed-article:360214 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:360214 | pubmed:dateCreated | 1978-12-27 | lld:pubmed |
| pubmed-article:360214 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:360214 | pubmed:abstractText | The pheA structural gene of the phenylalanine operon of Escherichia coli is preceded by a transcribed leader region of about 170 nucleotide pairs. In vitro transcription of plasmids and restriction fragments containing the phe promoter and leader region yields a major RNA transcript about 140 nucleotides in length. This transcript, pheA leader RNA, has the following features: (i) a potential ribosome binding site and AUG translation start codon about 20 nucleotides from its 5' end; (ii) 14 additional in phase amino acid codons and a UGA stop codon after the AUG; 7 of these 14 are Phe codons; (iii) a 3'-OH terminus about 140 nucleotides from the 5' end (transcription termination occurs in an A.T-rich region which is subsequent to a G.C-rich region; just beyond the site of transcription termination there is a sequence corresponding to a ribosome binding site and the AUG translation start codon of the pheA structural gene); (iv) a sequence which would permit extensive intrastrand stable hydrogen bonding. In addition to G.C-rich stem structures, highly analogous to those proposed for the leader RNAs of the tryptophan operons of E. coli and Salmonella typhimurium [Lee, F. & Yanofsky, C. (1977) Proc. Natl. Acad. Sci. USA 74, 4365-4369], there is also extensive base-pairing possible between the phe codon region and a more distal region of the leader transcript. The roles of synthesis of the Phe-rich leader peptide and secondary structure of the leader transcript in the regulation of transcription termination at the attenuator of the phe operon are discussed. | lld:pubmed |
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| pubmed-article:360214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:360214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:360214 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:360214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:360214 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:360214 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:360214 | pubmed:author | pubmed-author:BrownKK | lld:pubmed |
| pubmed-article:360214 | pubmed:author | pubmed-author:YanofskyCC | lld:pubmed |
| pubmed-article:360214 | pubmed:author | pubmed-author:ZurawskiGG | lld:pubmed |
| pubmed-article:360214 | pubmed:author | pubmed-author:KillinglyDD | lld:pubmed |
| pubmed-article:360214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:360214 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:360214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:360214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:360214 | pubmed:pagination | 4271-5 | lld:pubmed |
| pubmed-article:360214 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:360214 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:360214 | pubmed:articleTitle | Nucleotide sequence of the leader region of the phenylalanine operon of Escherichia coli. | lld:pubmed |
| pubmed-article:360214 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:360214 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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