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pubmed-article:3590212pubmed:abstractTextHedgehog (Erinaceus europaeus) plasma contains factor(s) which neutralize the hemorrhagic activity of European viper (Vipera berus) venom. These antihemorrhagic factor(s) were purified by gel filtration on Sephacryl S-200 and chromatography on Cibacron Blue Sepharose. The macroglobulin fraction obtained was characterized for proteinase inhibiting activity, molecular weight and purity by polyacrylamide gel electrophoresis and immunological cross-reactivity and was found to contain the three macroglobulin proteinase inhibitors--alpha 2-macroglobulin, alpha 2-beta-macroglobulin and beta-macroglobulin. The purified macroglobulins were totally able to neutralize Vipera berus venom hemorrhagic activity, but no distinction between them in this respect was possible.lld:pubmed
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pubmed-article:3590212pubmed:authorpubmed-author:WeströmB RBRlld:pubmed
pubmed-article:3590212pubmed:authorpubmed-author:de WitC ACAlld:pubmed
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pubmed-article:3590212pubmed:volume25lld:pubmed
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pubmed-article:3590212pubmed:pagination315-23lld:pubmed
pubmed-article:3590212pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:3590212pubmed:year1987lld:pubmed
pubmed-article:3590212pubmed:articleTitleVenom resistance in the hedgehog, Erinaceus europaeus: purification and identification of macroglobulin inhibitors as plasma antihemorrhagic factors.lld:pubmed
pubmed-article:3590212pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3590212pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:3590212pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed