| pubmed-article:3554401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3554401 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:3554401 | lifeskim:mentions | umls-concept:C0376180 | lld:lifeskim |
| pubmed-article:3554401 | lifeskim:mentions | umls-concept:C0043515 | lld:lifeskim |
| pubmed-article:3554401 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:3554401 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:3554401 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3554401 | pubmed:dateCreated | 1987-6-2 | lld:pubmed |
| pubmed-article:3554401 | pubmed:abstractText | The molecular species of gastrin in the circulation and in tumor extracts were studied in two groups of patients: (1) with benign gastrinoma and (2) with gastrinoma with liver metastases. Radioimmunoassays (RIAs) and immunoaffinity chromatography for the amino (NH2)- and amidated COOH-terminus of gastrin-17 (antiserum G17) and the NH2-terminus of gastrin-34 (antiserum G34) were employed. In both benign and metastatic tumors the molecular forms of gastrin in boiling water extracts measured by the gastrin-17 NH2- and COOH-terminal assays were similar. In addition to a molecular component resembling the amidated gastrin-17, there were also significant amounts of larger molecular weight (mol. wt.) forms. The larger mol. wt. forms absorbed by the NH2-terminus of G17 antiserum corresponded to the COOH-terminus-extended forms of gastrin-17. Furthermore, larger mol. wt. gastrins immunopurified by antiserum to the NH2-terminus of gastrin-34 corresponded to gastrin-34 extended molecules. Sera of patients with liver metastases had higher concentrations of the NH2-terminal of gastrin-17 whereas sera of patients with benign gastrinoma contained predominantly gastrins detected by the COOH-terminal assay. These results suggest that: (a) there are differences in the molecular pattern of gastrin in the circulation of patients with benign and metastatic gastrinomas; (b) gastrins which are fully processed with carboxy-terminal amidation predominate in the circulation of patients with benign gastrinoma; and (c) gastrins containing the gastrin-17 and COOH-terminally extended gastrin-17 and gastrin-34 precursor molecules occur in high concentration in the circulation of gastrinoma patients with metastases to the liver. | lld:pubmed |
| pubmed-article:3554401 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3554401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3554401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3554401 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3554401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3554401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3554401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3554401 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3554401 | pubmed:issn | 0167-0115 | lld:pubmed |
| pubmed-article:3554401 | pubmed:author | pubmed-author:VinikA IAI | lld:pubmed |
| pubmed-article:3554401 | pubmed:author | pubmed-author:MahoneyW CWC | lld:pubmed |
| pubmed-article:3554401 | pubmed:author | pubmed-author:KotharyP CPC | lld:pubmed |
| pubmed-article:3554401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3554401 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:3554401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3554401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3554401 | pubmed:pagination | 71-84 | lld:pubmed |
| pubmed-article:3554401 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:meshHeading | pubmed-meshheading:3554401-... | lld:pubmed |
| pubmed-article:3554401 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3554401 | pubmed:articleTitle | Identification of gastrin molecular variants in gastrinoma syndrome. | lld:pubmed |
| pubmed-article:3554401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3554401 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3554401 | lld:pubmed |
