pubmed-article:3537732 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C0042214 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C0032148 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C1624581 | lld:lifeskim |
pubmed-article:3537732 | lifeskim:mentions | umls-concept:C1293132 | lld:lifeskim |
pubmed-article:3537732 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:3537732 | pubmed:dateCreated | 1986-12-22 | lld:pubmed |
pubmed-article:3537732 | pubmed:abstractText | We show that the subcellular location of foreign antigens expressed in recombinant vaccinia viruses influences their effectiveness as immunogens. Live recombinant viruses induced very poor antibody responses to a secreted repetitive plasmodial antigen (the S-antigen) in rabbits and mice. The poor response accords with epidemiological data suggesting that S-antigens are poorly immunogenic. Appending the transmembrane domain of a membrane immunoglobulin (immunoglobulin G1) to its carboxy terminus produced a hybrid S-antigen that was no longer secreted but was located on the surface of virus-infected cells. This recombinant virus elicited high antibody titers to the S-antigen. This approach will facilitate the use of live virus delivery systems to immunize against a wide range of foreign nonsurface antigens. | lld:pubmed |
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pubmed-article:3537732 | pubmed:language | eng | lld:pubmed |
pubmed-article:3537732 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3537732 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:3537732 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3537732 | pubmed:month | Sep | lld:pubmed |
pubmed-article:3537732 | pubmed:issn | 0270-7306 | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:MitchellG FGF | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:KempD JDJ | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:AndersR FRF | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:LangfordC JCJ | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:SmithG LGL | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:MossBB | lld:pubmed |
pubmed-article:3537732 | pubmed:author | pubmed-author:EdwardsS JSJ | lld:pubmed |
pubmed-article:3537732 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3537732 | pubmed:volume | 6 | lld:pubmed |
pubmed-article:3537732 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3537732 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3537732 | pubmed:pagination | 3191-9 | lld:pubmed |
pubmed-article:3537732 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:3537732 | pubmed:year | 1986 | lld:pubmed |
pubmed-article:3537732 | pubmed:articleTitle | Anchoring a secreted plasmodium antigen on the surface of recombinant vaccinia virus-infected cells increases its immunogenicity. | lld:pubmed |
pubmed-article:3537732 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3537732 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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