| pubmed-article:3536878 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C0038615 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C1510824 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3536878 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3536878 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3536878 | pubmed:dateCreated | 1987-1-14 | lld:pubmed |
| pubmed-article:3536878 | pubmed:abstractText | Fumarate reductase (encoded by frd) and succinate dehydrogenase (encoded by sdh) of Escherichia coli are both known to catalyze the interconversion of fumarate and succinate. Fumarate reductase, however, is not inducible aerobically and therefore cannot participate in the dehydrogenation of succinate. Three classes of suppressor mutants, classified as frd oxygen-resistant [frd(Oxr)], constitutive [frd(Con)], and gene amplification [frd(Amp)] mutants, were selected from an sdh strain as pseudorevertants that regained the partial ability to grow aerobically on succinate. All contained increased aerobic levels of fumarate reductase activity. In frd(Oxr) mutants expression of the operon showed increased resistance to aerobic repression. Under anaerobic conditions expression of the operon became less dependent on the fnr+ gene product, a pleiotropic activator protein for genes encoding anaerobic respiratory enzymes. Exogenous fumarate, however, was still required for full induction, and repression by nitrate was undiminished. Thus, aerobic repression and anaerobic nitrate repression appear to involve separate mechanisms. In frd(Con) mutants expression of the operon became highly resistant to aerobic repression. Under anaerobic conditions expression of the operon no longer required the fnr+ gene product or exogenous fumarate and became immune to nitrate repression. In partial diploids bearing an frd(Oxr) or an frd(Con) allele and phi(frd+-lac) there was no mutual regulatory influence between the two genetic loci. Thus, the frd mutations act in cis and hence are probably in the promoter region. In frd(Amp) mutants the frd locus was amplified without significant alteration in the pattern of regulation. | lld:pubmed |
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| pubmed-article:3536878 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3536878 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3536878 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3536878 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3536878 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:3536878 | pubmed:author | pubmed-author:LinE CEC | lld:pubmed |
| pubmed-article:3536878 | pubmed:author | pubmed-author:KuritzkesD... | lld:pubmed |
| pubmed-article:3536878 | pubmed:author | pubmed-author:IuchiSS | lld:pubmed |
| pubmed-article:3536878 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3536878 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:3536878 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3536878 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3536878 | pubmed:pagination | 1415-21 | lld:pubmed |
| pubmed-article:3536878 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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| pubmed-article:3536878 | pubmed:meshHeading | pubmed-meshheading:3536878-... | lld:pubmed |
| pubmed-article:3536878 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3536878 | pubmed:articleTitle | Three classes of Escherichia coli mutants selected for aerobic expression of fumarate reductase. | lld:pubmed |
| pubmed-article:3536878 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3536878 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3536878 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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