| pubmed-article:3536270 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C0042396 | lld:lifeskim |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C0040061 | lld:lifeskim |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:3536270 | lifeskim:mentions | umls-concept:C0106665 | lld:lifeskim |
| pubmed-article:3536270 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3536270 | pubmed:dateCreated | 1986-12-31 | lld:pubmed |
| pubmed-article:3536270 | pubmed:abstractText | We investigated the effect of a thromboxane antagonist, BM 13.177, during endotoxin-induced pulmonary vasoconstriction in sheep. In control animals intravenous E-coli endotoxin (1 microgram/kg) caused a transient increase of pulmonary artery and airway pressure paralleled by large concentration increases of TXB2: in comparison peak plasma concentrations of 6-keto-PGF1 alpha (a prostacyclin metabolite) were small and delayed in time. Pre-treatment with BM 13.177 (bolus 5 mg/kg), followed by 0.75 mg/kg/min intravenously) abolished the rise of pulmonary artery and airway pressure. Plasma concentrations of TXB2 and 6-keto-PGF1 alpha were similar to controls. These and previous investigations imply that BM 13.177 specifically antagonizes TXA2 on the putative receptor in pulmonary vascular and airway smooth muscle. | lld:pubmed |
| pubmed-article:3536270 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3536270 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3536270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3536270 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3536270 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3536270 | pubmed:issn | 0144-5979 | lld:pubmed |
| pubmed-article:3536270 | pubmed:author | pubmed-author:QvistJJ | lld:pubmed |
| pubmed-article:3536270 | pubmed:author | pubmed-author:MogensenTT | lld:pubmed |
| pubmed-article:3536270 | pubmed:author | pubmed-author:BellMM | lld:pubmed |
| pubmed-article:3536270 | pubmed:author | pubmed-author:EliasenKK | lld:pubmed |
| pubmed-article:3536270 | pubmed:author | pubmed-author:SørensenJ NJN | lld:pubmed |
| pubmed-article:3536270 | pubmed:author | pubmed-author:HüttemeierPP | lld:pubmed |
| pubmed-article:3536270 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3536270 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3536270 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3536270 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3536270 | pubmed:pagination | 415-22 | lld:pubmed |
| pubmed-article:3536270 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:meshHeading | pubmed-meshheading:3536270-... | lld:pubmed |
| pubmed-article:3536270 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3536270 | pubmed:articleTitle | Effects of a thromboxane antagonist (BM 13.177) during endotoxin-induced pulmonary vasoconstriction in sheep. | lld:pubmed |
| pubmed-article:3536270 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3536270 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3536270 | lld:pubmed |
