| pubmed-article:3528863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0023440 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C1880287 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3528863 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:3528863 | pubmed:issue | 6082 | lld:pubmed |
| pubmed-article:3528863 | pubmed:dateCreated | 1986-10-8 | lld:pubmed |
| pubmed-article:3528863 | pubmed:abstractText | Friend murine erythroleukaemia (F-MEL) cells are a permanent line of primitive erythroid precursors originally derived from the spleens of mice infected with the Friend strain of murine leukaemia virus. F-MEL cells differentiate in vitro in response to various chemical inducers. Concomitantly with induction, a biphasic regulation of c-myc oncogene transcripts is observed. Within one hour of the addition of dimethyl sulphoxide (DMSO) or hypoxanthine (Hyp), the levels of c-myc transcripts fall dramatically and remain virtually undetectable for the next few hours. Between 8 and 24 hours after induction, c-myc transcripts return to pre-induction levels and then decline again between 3 and 5 days as most of the cells undergo terminal differentiation. To explore the potential relationship between c-myc expression and F-MEL terminal differentiation, we have investigated here whether reversing the early fluctuations in c-myc transcript levels affects the ability of F-MEL cells to differentiate. We therefore constructed an amplifiable plasmid vector containing a full-length mouse c-myc complementary DNA and introduced it stably into recipient F-MEL cells. The exogenous c-myc sequences are transcribed in F-MEL cells and the transcript levels do not change significantly in response to inducing agents. The net result is continued c-myc expression following DMSO or Hyp induction and a complete or partial inhibition of F-MEL differentiation. | lld:pubmed |
| pubmed-article:3528863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3528863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3528863 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3528863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3528863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3528863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3528863 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3528863 | pubmed:author | pubmed-author:ProchownikE... | lld:pubmed |
| pubmed-article:3528863 | pubmed:author | pubmed-author:KukowskaJJ | lld:pubmed |
| pubmed-article:3528863 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3528863 | pubmed:volume | 322 | lld:pubmed |
| pubmed-article:3528863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3528863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3528863 | pubmed:pagination | 848-50 | lld:pubmed |
| pubmed-article:3528863 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3528863 | pubmed:meshHeading | pubmed-meshheading:3528863-... | lld:pubmed |
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| pubmed-article:3528863 | pubmed:articleTitle | Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation. | lld:pubmed |
| pubmed-article:3528863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3528863 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3528863 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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