| pubmed-article:3526329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3526329 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:3526329 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3526329 | lifeskim:mentions | umls-concept:C1454488 | lld:lifeskim |
| pubmed-article:3526329 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:3526329 | pubmed:dateCreated | 1986-9-17 | lld:pubmed |
| pubmed-article:3526329 | pubmed:abstractText | We have made Chinese hamster ovary (CHO) cell lines that contain up to 2000 copies of the coding region of the mouse c-myc gene fused to the promoter of the Drosophila gene (hsp70) encoding a Mr 70,000 heat shock protein. Incubation of these cells at 43 degrees C results in an estimated 100-fold induction of c-myc mRNA. Translation of this mRNA occurs when the cells are returned to 37 degrees C, and during the first 3 hr of recovery at 37 degrees C, the c-myc protein is one of the most abundantly synthesized proteins in the cells. The products of the induced c-myc gene are phosphoproteins of apparent Mr 64,000, 66,000, and 75,000. Induced cells die, suggesting that elevated levels of c-myc are cytotoxic. Amplification of genes placed under control of the Drosophila hsp70 promoter may provide a general method for inducibly over expressing proteins in mammalian cells. | lld:pubmed |
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| pubmed-article:3526329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3526329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3526329 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3526329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3526329 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3526329 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3526329 | pubmed:author | pubmed-author:KingstonR ERE | lld:pubmed |
| pubmed-article:3526329 | pubmed:author | pubmed-author:WurmF MFM | lld:pubmed |
| pubmed-article:3526329 | pubmed:author | pubmed-author:GwinnK AKA | lld:pubmed |
| pubmed-article:3526329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3526329 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3526329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3526329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3526329 | pubmed:pagination | 5414-8 | lld:pubmed |
| pubmed-article:3526329 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3526329 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3526329 | pubmed:articleTitle | Inducible overproduction of the mouse c-myc protein in mammalian cells. | lld:pubmed |
| pubmed-article:3526329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3526329 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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