| pubmed-article:3515291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3515291 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:3515291 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:3515291 | lifeskim:mentions | umls-concept:C0184567 | lld:lifeskim |
| pubmed-article:3515291 | lifeskim:mentions | umls-concept:C1373045 | lld:lifeskim |
| pubmed-article:3515291 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:3515291 | lifeskim:mentions | umls-concept:C0771172 | lld:lifeskim |
| pubmed-article:3515291 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3515291 | pubmed:dateCreated | 1986-4-25 | lld:pubmed |
| pubmed-article:3515291 | pubmed:abstractText | D-Phenylalanine, along with morphine, acetylsalicylic acid and zomepirac sodium were evaluated for their antinociceptive actions in monkeys (M. fascicularis) trained to autoregulate nociceptive stimulation using a discrete-trials, aversive-threshold paradigm. Morphine sulfate produced dose-related increases in aversive threshold which were reversible after administration of naloxone (12.5 or 25 micrograms/kg i.m.). D-Phenylalanine (500 mg/kg p.o.) produced a small increase in aversive threshold which was not statistically significant and not naloxone reversible. Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produced a small statistically significant increase in aversive threshold. Our results argue against the hypothesis that D-phenylalanine is responsible for increasing aversive thresholds via opiate receptor mechanisms involving increased activity of enkephalins at synaptic loci. Previous studies by others in rats and mice showed that D-phenylalanine and acetylsalicylic acid produced increases in nociceptive thresholds which were naloxone reversible. Our failure to find opiate receptor mediated analgesia in a primate model with demonstrated opiate receptor selectivity and sensitivity is discussed in terms of previous basic and clinical research indicating an analgesic role for D-phenylalanine. Possible species difference in drug action is discussed in terms of inhibition by D-phenylalanine of carboxy-peptidase-like enkephalin processing enzymes as well as inhibition of carboxypeptidase-like enkephalin degrading enzymes. | lld:pubmed |
| pubmed-article:3515291 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3515291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3515291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3515291 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3515291 | pubmed:issn | 0304-3959 | lld:pubmed |
| pubmed-article:3515291 | pubmed:author | pubmed-author:HalpernL MLM | lld:pubmed |
| pubmed-article:3515291 | pubmed:author | pubmed-author:DongW KWK | lld:pubmed |
| pubmed-article:3515291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3515291 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:3515291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3515291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3515291 | pubmed:pagination | 223-37 | lld:pubmed |
| pubmed-article:3515291 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3515291 | pubmed:meshHeading | pubmed-meshheading:3515291-... | lld:pubmed |
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| pubmed-article:3515291 | pubmed:meshHeading | pubmed-meshheading:3515291-... | lld:pubmed |
| pubmed-article:3515291 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3515291 | pubmed:articleTitle | D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model. | lld:pubmed |
| pubmed-article:3515291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3515291 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3515291 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3515291 | lld:pubmed |
