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pubmed-article:3503110pubmed:abstractTextThe effects of the d- and 1-isomers of epinephrine and norepinephrine have been determined on intraocular pressure (IOP) in conscious rabbits and rhesus monkeys, and on aqueous humor turnover rate (AHTR) in rabbits. Relatively specific beta-adrenergic antagonists (butoxamine and metoprolol) were used to attempt to modify the responses. The effects on IOP in both species are similar to those of racemic mixtures. The d- and 1-isomers of norepinephrine and epinephrine reduced IOP, and reduced AHTR in rabbits. The d- and 1-isomers of norepinephrine had little effect on IOP in monkeys while d- and 1-epinephrine increased IOP. Metoprolol, a beta 1-antagonist was more effective than butoxamine (beta 2-antagonist) at modifying the effect of the norepinephrine isomers in rabbits.lld:pubmed
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pubmed-article:3503110pubmed:authorpubmed-author:ElijahR DRDlld:pubmed
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pubmed-article:3503110pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:3503110pubmed:articleTitleIntraocular pressure and aqueous humor dynamics in rabbit and primate with d- and 1-adrenergic compounds.lld:pubmed
pubmed-article:3503110pubmed:affiliationDepartment of Ophthalmology, Medical College of Georgia, Augusta.lld:pubmed
pubmed-article:3503110pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3503110pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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