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| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0012925 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C1519877 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0524891 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:3502705 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3502705 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3502705 | pubmed:dateCreated | 1987-6-25 | lld:pubmed |
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| pubmed-article:3502705 | pubmed:abstractText | We have identified circular DNA containing T cell receptor (TCR) beta gene sequences in mouse thymocytes, thereby providing direct evidence for the intramolecular DNA deletion model of V-D-J joining in TCR beta genes. Two types of excision products of V-D-J joining have been identified. Type I, a circular reciprocal recombinant of normal V-D or D-J joining, contains a 7mer-7mer head-to-head structure expected from an excised product of normal V-D or D-J joining. Type II contains a D beta 2-J beta 1 structure on the circular DNA; the recombination event producing this molecule occurs between an upstream J and a downstream D segment, probably leaving the reciprocal 7mer-7mer structure on the chromosome. Some type I molecules seem to represent excision products of secondary joining after formation of the first D-J or V-D-J structure. The recombination mechanism that generates the circular DNA is discussed. | lld:pubmed |
| pubmed-article:3502705 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3502705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3502705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3502705 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3502705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3502705 | pubmed:month | May | lld:pubmed |
| pubmed-article:3502705 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:3502705 | pubmed:author | pubmed-author:OkazakiKK | lld:pubmed |
| pubmed-article:3502705 | pubmed:author | pubmed-author:SakanoHH | lld:pubmed |
| pubmed-article:3502705 | pubmed:author | pubmed-author:DavisD DDD | lld:pubmed |
| pubmed-article:3502705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3502705 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:3502705 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:3502705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3502705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3502705 | pubmed:pagination | 477-85 | lld:pubmed |
| pubmed-article:3502705 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3502705 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3502705 | pubmed:articleTitle | T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining. | lld:pubmed |
| pubmed-article:3502705 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3502705 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3502705 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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