| pubmed-article:3500954 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3500954 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:3500954 | lifeskim:mentions | umls-concept:C2246364 | lld:lifeskim |
| pubmed-article:3500954 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:3500954 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:3500954 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:3500954 | pubmed:dateCreated | 1988-2-20 | lld:pubmed |
| pubmed-article:3500954 | pubmed:abstractText | Filaments formed from phosphorylated smooth muscle myosin are stable in the presence of MgATP, whereas dephosphorylated filaments are disassembled to a mixture of folded monomers and dimers. The stability of copolymers of phosphorylated and dephosphorylated myosin was, however, unknown. Gel filtration, sedimentation velocity, and pelleting assays were used to show that MgATP could dissociate dephosphorylated myosin from copolymers containing either rod and myosin or dephosphorylated and phosphorylated myosin. Copolymers were typically formed by dialyzing monomeric mixtures into filament-forming buffer but, unexpectedly, could also be formed within minutes of mixing preformed rod and myosin minifilaments. This result suggested that molecules can rapidly and extensively exchange between filaments, presumably via the monomeric pool of myosin in equilibrium with polymer. An exchange of molecules between filaments was demonstrated directly by electron microscopy using gold-labeled streptavidin or antibody to detect the exchanged species. By this approach it was shown that smooth muscle myosin filaments, like other macromolecular assemblies, are dynamic structures that can readily alter their composition in response to changing solvent conditions. Moreover, because folded monomeric myosin is unable to polymerize, these experiments suggest a mechanism for the disassembly of the filament by MgATP. | lld:pubmed |
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| pubmed-article:3500954 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3500954 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3500954 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3500954 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3500954 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3500954 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:3500954 | pubmed:author | pubmed-author:LoweySS | lld:pubmed |
| pubmed-article:3500954 | pubmed:author | pubmed-author:TrybusK MKM | lld:pubmed |
| pubmed-article:3500954 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3500954 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:3500954 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3500954 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3500954 | pubmed:pagination | 3021-30 | lld:pubmed |
| pubmed-article:3500954 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:3500954 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3500954 | pubmed:articleTitle | Subunit exchange between smooth muscle myosin filaments. | lld:pubmed |
| pubmed-article:3500954 | pubmed:affiliation | Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02254. | lld:pubmed |
| pubmed-article:3500954 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3500954 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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