| pubmed-article:3499373 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3499373 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3499373 | lifeskim:mentions | umls-concept:C0010132 | lld:lifeskim |
| pubmed-article:3499373 | lifeskim:mentions | umls-concept:C0015328 | lld:lifeskim |
| pubmed-article:3499373 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:3499373 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:3499373 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:3499373 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3499373 | pubmed:dateCreated | 1987-12-2 | lld:pubmed |
| pubmed-article:3499373 | pubmed:abstractText | Corticotropin-releasing factor (CRF) administered intracerebroventricularly (ICV) to rats and mice has been shown to elicit a variety of behaviors resembling those that occur in stress. In a novel multicompartment chamber, ICV CRF altered the behaviors in a manner closely resembling that observed following a period of restraint. In particular, 75 ng CRF ICV or 30-40 min restraint markedly reduced the time mice spent in contact with novel stimuli. ICV injections of a peptide antagonist of CRF, alpha-helical CRF9-41 (ahCRF), reversed the effects of restraint on this measure. This effect of ahCRF was dose dependent, with a minimal effective dose of 10 micrograms. Other behavioral measures appeared normal, and ahCRF did not significantly alter the stimulus-contact time in unrestrained mice. These results provide strong evidence to support the hypothesis that endogenous CRF may be a factor affecting stress-induced changes in exploratory behavior in mice. | lld:pubmed |
| pubmed-article:3499373 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3499373 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3499373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3499373 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3499373 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3499373 | pubmed:issn | 0018-506X | lld:pubmed |
| pubmed-article:3499373 | pubmed:author | pubmed-author:DunnA JAJ | lld:pubmed |
| pubmed-article:3499373 | pubmed:author | pubmed-author:BerridgeC WCW | lld:pubmed |
| pubmed-article:3499373 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3499373 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:3499373 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3499373 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3499373 | pubmed:pagination | 393-401 | lld:pubmed |
| pubmed-article:3499373 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:meshHeading | pubmed-meshheading:3499373-... | lld:pubmed |
| pubmed-article:3499373 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3499373 | pubmed:articleTitle | A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice. | lld:pubmed |
| pubmed-article:3499373 | pubmed:affiliation | Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610. | lld:pubmed |
| pubmed-article:3499373 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3499373 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3499373 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3499373 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3499373 | lld:pubmed |
