| pubmed-article:3496542 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3496542 | lifeskim:mentions | umls-concept:C0001175 | lld:lifeskim |
| pubmed-article:3496542 | lifeskim:mentions | umls-concept:C0024115 | lld:lifeskim |
| pubmed-article:3496542 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:3496542 | lifeskim:mentions | umls-concept:C0449435 | lld:lifeskim |
| pubmed-article:3496542 | pubmed:issue | 6128 | lld:pubmed |
| pubmed-article:3496542 | pubmed:dateCreated | 1987-8-26 | lld:pubmed |
| pubmed-article:3496542 | pubmed:abstractText | Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome). HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans and apes. We describe an experimental system permitting the quantitative and systematic analysis of HIV-specific cytotoxic T lymphocytes (CTL). Functional, HIV-specific CTL are obtained by broncho-alveolar lavage (BAL) from the lungs of seropositive patients with lymphocytic alveolitis. These alveolar CTL: (1) recognize and kill HIV-infected alveolar macrophages in vitro under autologous, but not heterologous, conditions; (2) correspond to standard CTL as they express the CD3 and CD8 surface markers, but not the CD4 marker; and (3) are restricted by class I HLA transplantation antigens in their cytotoxic activities. We propose the hypothesis that interactions between HIV-specific CTL and infected macrophages induce major inflammatory reactions in seropositive patients. | lld:pubmed |
| pubmed-article:3496542 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3496542 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3496542 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3496542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3496542 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3496542 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:Wain-HobsonSS | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:DebréPP | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:PlataFF | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:DenisMM | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:MayaudCC | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:RaphaëlMM | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:AutranBB | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:GuillonJ MJM | lld:pubmed |
| pubmed-article:3496542 | pubmed:author | pubmed-author:MartinsL PLP | lld:pubmed |
| pubmed-article:3496542 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3496542 | pubmed:volume | 328 | lld:pubmed |
| pubmed-article:3496542 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3496542 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3496542 | pubmed:pagination | 348-51 | lld:pubmed |
| pubmed-article:3496542 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3496542 | pubmed:meshHeading | pubmed-meshheading:3496542-... | lld:pubmed |
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| pubmed-article:3496542 | pubmed:meshHeading | pubmed-meshheading:3496542-... | lld:pubmed |
| pubmed-article:3496542 | pubmed:articleTitle | AIDS virus-specific cytotoxic T lymphocytes in lung disorders. | lld:pubmed |
| pubmed-article:3496542 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3496542 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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